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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Monday, August 16, 2010

1999 Letter in the Lancet about 'periodic' Trimethylaminuria

Of the handful of researchers who have investigated trimethylaminuria, probably the most research into the physical side of the odor problem (rather than genetic research) has been done by Dr Stephen Mitchell of  Imperial College in London (Dr SC Mitchell TMAU papers on pubmed), most of his research being in the late 80's and 90's (very little over this decade) 

In this 1999 letter to the Lancet, he comments that in his experience, many sufferers who have TMAU  are likely to be 'carriers' who only smell periodically when their FMO3 enzyme is called upon to deal with bigger loads of TMA. He explains that they have no 'reserve capacity' as normal people do. It is interesting he chooses to reply to this medical paper done by Zschocke et al, since this paper demonstrated that TMAU can include those with 2 copies of common 'mild' FMO3 variants, again being a transient form of TMAU.

TMAU, if ever discussed at medical school, is likely still regarded as a disorder affecting those with 2 mutant copies, which typically is very 'severe' and rare.
  Over the past decade we have encountered many patients who have odour problems on a mild, transient, and periodic basis. These otherwise healthy individuals are presumably heterozygotes, or compound heterozygotes, who can cope with the daily burden of trimethylamine (TMA), but have little, if any, reserve capacity when stressed by other factors and may fail to metabolically breakdown trimethylamine. To raise the general awareness of this disorder and reiterate that it “is not merely a rare recessive disorder but rather a spectrum of phenotypes of transient or mild malodour” is important, but it is also imperative to realise that fish-odour syndrome is not a simple genetic problem and that heterozygotes (carriers) may have to endure a transient and more elusive form of this complaint initiated by various, less obvious, and more ephemeral, factors.


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