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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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MEBO survey for Dr Hazen click here
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Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

MEBO Research Clinical Trials

Tuesday, August 24, 2010

Carnitine : not just choline to be avoided in TMAU diet

Those interested in TMAU are very aware that choline is to be kept minimal in the disorder, since gut bacteria can metabolize the choline, with one resulting metabolite being trimethylamine (TMA). However it may be often overlooked that another compound that can result in TMA production is carnitine.

The 'avoidance' diet strategy for TMAU mainly involves :

1. Keeping anything that can result in TMA to a minimum
obvious examples :
  • Choline (remember this is an essential nutrient though)
  • Any food with high TMA-oxide content, since the TMA-oxide is broken down to TMA in our gut (e.g. seafood)
  • Carnitine

2. Avoiding anything that inhibits the FMO3 enzyme
So far, only indoles in cruciferous veg have been proven to inhibit the enzyme. It's possible more foods are to be discovered.

In humans, most carnitine in the diet is derived from lysine and methionine, so anything high in these 2 amino acids will naturally result in the most carnitine. This shows how difficult it is to avoid, given that lysine and methionine are in many foods. 2 common main sources are red meat and in the whey portion of dairy foods. But red meat is the most abundant food by far, as can be seen in the table in this page : Office of Dietary Supplements info on carnitine

For those that feel only trimethylamine causes their odor, perhaps carnitine is worth further investigation to see if this could be a secret source of TMA in your diet. In general, it seems that those on a strict vegetarian or vegan diet may have very little carnitine in their diet, but it must be remembered that lysine and methionine are essential amino acids.

http://en.wikipedia.org/wiki/Carnitine
http://ods.od.nih.gov/factsheets/carnitine.asp

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