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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country

MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Friday, August 20, 2010

1999 postgraduate overview of Trimethylaminuria

This seems to be a postgraduate thesis on trimethylaminuria, but is quite a good summary of the condition and still relevant today. Written by H Rehman while they were at Hull Royal Infirmary, UK.

Some interesting quotes :

Trimethylaminuria was thought to be a rare condition, but evidence suggests
that its prevalence is much higher than initially thought. In a study involving 82
Jordanian subjects, eight subjects (9.7%) excreted less than 80% of their total
trimethylamine as trimethylamine oxide.4 A similar study showed 1.7% of the
Jordanian population, 3.8% of the Ecuadorian population and 11% of the New
Guinean population excreted less than 80% of their total trimethylamine as the
N-oxide.5 In another study involving 421 British white volunteers, 16 subjects
(3.8%) excreted less than 90% of their total trimethylamine output as N-oxide,
of which six subjects (1.4%) excreted less than 80% as N-oxide.6

Normal individuals excrete about 1 mg of
trimethylamine and 50 mg of trimethylamine oxide in the urine in 24 hours, but
excretion varies with diet. N-Oxide enzymatic oxidation capacity is rarely
exceeded on an average diet. However, normal individuals can smell of rotting
fish if 20 g of pure choline is given to them orally.10 This is because of the resultant
excessive production of trimethylamine, which exceeds the capacity of the
normal healthy liver to oxidise it to a non-odorous oxide.

Full TMAU overview in PDF format

1999 TMAU overview abstract


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