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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Friday, August 20, 2010

1999 postgraduate overview of Trimethylaminuria

This seems to be a postgraduate thesis on trimethylaminuria, but is quite a good summary of the condition and still relevant today. Written by H Rehman while they were at Hull Royal Infirmary, UK.

Some interesting quotes :

Trimethylaminuria was thought to be a rare condition, but evidence suggests
that its prevalence is much higher than initially thought. In a study involving 82
Jordanian subjects, eight subjects (9.7%) excreted less than 80% of their total
trimethylamine as trimethylamine oxide.4 A similar study showed 1.7% of the
Jordanian population, 3.8% of the Ecuadorian population and 11% of the New
Guinean population excreted less than 80% of their total trimethylamine as the
N-oxide.5 In another study involving 421 British white volunteers, 16 subjects
(3.8%) excreted less than 90% of their total trimethylamine output as N-oxide,
of which six subjects (1.4%) excreted less than 80% as N-oxide.6

Normal individuals excrete about 1 mg of
trimethylamine and 50 mg of trimethylamine oxide in the urine in 24 hours, but
excretion varies with diet. N-Oxide enzymatic oxidation capacity is rarely
exceeded on an average diet. However, normal individuals can smell of rotting
fish if 20 g of pure choline is given to them orally.10 This is because of the resultant
excessive production of trimethylamine, which exceeds the capacity of the
normal healthy liver to oxidise it to a non-odorous oxide.

Full TMAU overview in PDF format

1999 TMAU overview abstract


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