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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Friday, August 20, 2010

1999 postgraduate overview of Trimethylaminuria

This seems to be a postgraduate thesis on trimethylaminuria, but is quite a good summary of the condition and still relevant today. Written by H Rehman while they were at Hull Royal Infirmary, UK.

Some interesting quotes :

Trimethylaminuria was thought to be a rare condition, but evidence suggests
that its prevalence is much higher than initially thought. In a study involving 82
Jordanian subjects, eight subjects (9.7%) excreted less than 80% of their total
trimethylamine as trimethylamine oxide.4 A similar study showed 1.7% of the
Jordanian population, 3.8% of the Ecuadorian population and 11% of the New
Guinean population excreted less than 80% of their total trimethylamine as the
N-oxide.5 In another study involving 421 British white volunteers, 16 subjects
(3.8%) excreted less than 90% of their total trimethylamine output as N-oxide,
of which six subjects (1.4%) excreted less than 80% as N-oxide.6

Normal individuals excrete about 1 mg of
trimethylamine and 50 mg of trimethylamine oxide in the urine in 24 hours, but
excretion varies with diet. N-Oxide enzymatic oxidation capacity is rarely
exceeded on an average diet. However, normal individuals can smell of rotting
fish if 20 g of pure choline is given to them orally.10 This is because of the resultant
excessive production of trimethylamine, which exceeds the capacity of the
normal healthy liver to oxidise it to a non-odorous oxide.

Full TMAU overview in PDF format

1999 TMAU overview abstract


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