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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Wednesday, December 14, 2011

Choline is important for liver health

Professor Steven Zeisel is probably the leading figure in knowledge of and research into choline. He was mainly responsible for the choline datasheet on the USA government agency website (USDA choline database)

Whilst those who feel Trimethylaminuria (TMAU) fully explains their odor condition are obviously going to greatly reduce choline as the central theme of their 'anti-TMAU protocol', unfortunately it seems that choline may be quite important for liver health and it seems a choline deficiency can potentially cause 'reversible fatty liver' and in some cases do more damage. It seems from Dr Zeisel's papers that damage may also be partly due to those genetically predisposed to small common DNA 'polymorphisms' that may reduce efficient metabolism of choline, and that not everyone is 'susceptible' to problems.

It is a'spanner' in the works of the 'TMAU protocol', and so is worthy of mention. How relevant or likely it is an issue to each person, we do not know. It would probably seem best not to limit choline completely, and instead go for a 'low choline' diet rather than 'no choline'.

There has also been some suggestion that phoshatidylcholine is poorly metabolized into trimethylamine by gut bacteria and so may even be a good source of choline for those with TMAU. However, we do not know how well phosphatidylocholine is absorbed by humans.

Some Papers by Prof Zeisel on the need for choline

Dietary choline deficiency causes DNA strand breaks...
Nutritional genomics: defining the dietary requirement and effects of choline
...human gastrointestinal microbiome and development of fatty liver...
Dietary choline requirements of women...
Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline


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