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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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at UK Findacure conf 2020

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Wednesday, December 14, 2011

Choline is important for liver health

Professor Steven Zeisel is probably the leading figure in knowledge of and research into choline. He was mainly responsible for the choline datasheet on the USA government agency website (USDA choline database)

Whilst those who feel Trimethylaminuria (TMAU) fully explains their odor condition are obviously going to greatly reduce choline as the central theme of their 'anti-TMAU protocol', unfortunately it seems that choline may be quite important for liver health and it seems a choline deficiency can potentially cause 'reversible fatty liver' and in some cases do more damage. It seems from Dr Zeisel's papers that damage may also be partly due to those genetically predisposed to small common DNA 'polymorphisms' that may reduce efficient metabolism of choline, and that not everyone is 'susceptible' to problems.

It is a'spanner' in the works of the 'TMAU protocol', and so is worthy of mention. How relevant or likely it is an issue to each person, we do not know. It would probably seem best not to limit choline completely, and instead go for a 'low choline' diet rather than 'no choline'.

There has also been some suggestion that phoshatidylcholine is poorly metabolized into trimethylamine by gut bacteria and so may even be a good source of choline for those with TMAU. However, we do not know how well phosphatidylocholine is absorbed by humans.

Some Papers by Prof Zeisel on the need for choline

Dietary choline deficiency causes DNA strand breaks...
Nutritional genomics: defining the dietary requirement and effects of choline
...human gastrointestinal microbiome and development of fatty liver...
Dietary choline requirements of women...
Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline


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