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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Sunday, September 2, 2012

TMAU result stats from Sheffield UK 1997-2011

As part of conference at the recent MEBO Research Miami Beach Meetup in June, Nigel Manning, Principal Clinical Scientist in the department of Metabolic Biochemistry at Sheffield Children's Hospital (i.e. the UK TMAU tester), kindly provided MEBO with the latest statistics on their urine (phenotype) triemthylaminuria testing program.

A bar graph and dot graph were kindly provided. A trend of note was the bar graph shows that TMAU testing requests increased significantly since 2006, and especially over the last 2 years (to nearly 600 requests per year).

Note : Each TMAu lab sets their own reference range. The Sheffield ref ranges using gas chromatography are :
TMA concentration normal : 2.5-10.9 umol/mmol creatinine
TMAO normal : 17-147 umol/mmol creatinine
TMA/TMAO ratio normal : 0.05-0.21 (% TMAO should be, according to diagram, >79%)

bar graph of Sheffield TMAU results 97-11
dot graph of Sheffield TMAU results 97-11

PDF : Sheffield UK TMAU results 1997-2011 as a bar graph
PDF : Sheffield UK TMAU results in a dot graph with reference range lines

MEBO Research


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