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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
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BO Sufferers Podcasts

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Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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UK residents survey : Prof Shephard/MEBO (until 31/1/21) click to visit survey
click to Read more/less

Prof Elizabeth Shephard is conducting a TMAU fact-finding survey for UK RESIDENTS. She plans to use it to raise awareness with decision-makers, such as perhaps MPs. It closes 31 Jan 21.

who is the survey intended for ?
UK residents who identify with TMAU

Living with TMAU study

We invite you to participate in a research project entitled ‘Living with TMAU’.

click to visit survey

survey full url :
https://meboresearch.co.uk/index.php/living-with-tmau-lwtmau-study/

Participation in the project will involve completion of a short questionnaire, which aims to capture the experiences of those living with the condition. There are two questionnaires.

For individuals with TMAU over the age of 18

For a parent or guardian of a child with TMAU.

The results from the questionnaires will be compiled to produce a report that will be available for you to use, for example, to lobby your MP. The findings will be used to reach out to policy makers in the UK to have TMAU recognised as an invisible disability and to make people aware of what it is like to live with the disorder. The report will be made available on the MEBO, UK website.

To complete either questionnaire you must be over 18 and resident in the UK. The questionnaire responses are anonymous and no personal identifiers will be collected.

The questionnaire closes 11:59 pm (GMT) Sunday 31st January 2021.

MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Wednesday, December 18, 2013

Starvation Diet and Odor

Much too frequently, sufferers say that they are trying to stay on a very strict low choline diet, that they are losing a great deal of weight, and basically just following the TMAU odor-management protocol to an extreme degree. Nonetheless, they still claim to be emitting odor. After this attempt, some sufferers simply arrive at the conclusion that they fall into the group of TMAU+ sufferers for whom the protocol simply doesn't work.

I would like to invite these sufferers to examine one more aspect of the effects of the protocol they are following. Perhaps measuring the ketone levels in urine might give an indication of what could be going wrong.

Usually, when going on a very strict diet, sometimes referred to as a starvation and unhealthy diet, our bodies produce excess ketones, as an indication that it is using an alternative source of energy. Ketones are metabolic end-products of fatty acid metabolism. As Cass Nelson-Dooley, Clinical Consultant at Metametrix tells us in her March 24, 2009 interview for the MEBO Blog,


The smell of feces comes from short chain fatty acids (SCFAs) and bacteria like E. coli. All the SCFAs have strong smells. Butyric acid is an SCFA and it smells like feces and even like body odor. E .coli has more of a mousy odor.

So basically, by going on an unbalanced, extremely strict low choline diet, we may very well be decreasing our odorous TMA level in our blood, but then we are putting our fatty acid metabolism on overdrive, producing a feces-like odor...

precisely as a result of the very strict diet, some inadvertently create another metabolic condition that actually produces a different source of odor.
When this happens, ketone bodies show up in our urine, which is an indication that there is a strong probability that we are emit body and breath odor. One can purchase an inexpensive kit called Ketostix Reagent Strips for Urinalysis to test for elevated ketone levels. Basically, what you could do is dip one of the strips into your urine and see what color it turns into.

Unfortunately, sufferers believe that if they have TMAU, they have to starve themselves to keep TMA levels down. Sadly, precisely as a result of the very strict diet, some inadvertently create another metabolic condition that actually produces a different source of odor. Then, sufferers may feel that they don't have enough energy to do cardiovascular exercise because they don't eat enough food, so they fail to assist their cleansing organs like the lungs, kidneys and skin to clean the blood quickly and efficiently through the breath, perspiration and urine.

I recommend that sufferers read the post, "What to eat on a TMAU Low-Choline Diet," and to use Sonya McClinton's Simply Delicious: A Low Choline Recipe Book, as a tool to help develop a healthy diet. Her book includes seventy-five low choline recipes with the choline content and serving size listed for each. Categories include Light and Easy Breakfast Recipes, Simple Lunches, Delightful Dinners, Super Sides, and Decadent Desserts. These Delightful recipes prove that a diet low in choline does not have to be bland and tasteless. See links below to purchase your online/Kindle e-book. Sonya is a sufferer who wrote this recipe book to help other sufferers, and the cost is only $15.

Click here for Amazon US
Click here for Amazon UK







Note : If you don't have a kindle, if you click through the links above there is details on the right hand side of the page on how to download a free app to enable you to read the book on any device (PC, smartphone, ipad, tablet etc)   



The key is to not let one's body go into starvation mode and to avoid relying on fatty acid metabolism for energy for long periods of time. Relying solely on fatty acid metabolism for energy increases ketone levels (odorous metabolic end-products of fatty acid metabolism) in urine, and long term absence of protein, carbs, fruits and vegetables is harmful to the intestines. Ask any gastroenterologist. Instead, the goal is to eat a healthy diet by working closely with the rate of our own individual metabolism by spreading out a relatively low choline intake throughout the day to "work with" our FMO3.

If your TMAU metabolic pathway is deficient, then break up one well balanced meal into two or more smaller meals to allow your metabolic enzyme to "keep up" with the daily necessary food intake in order to prevent it form allowing free odorous chemicals into the bloodstream.

Please don't do strenuous cardiovascular exercise inf you have put your body into "starvation mode" as your home ketone test may indicate. Eat healthy with enough calories and choline to stay healthy and to give you enough energy to do cardiovascular exercise in an effort to assist your cleansing organs, in order to not have odor.

I hope I have explained this in simple terms so that it makes sense. Best of luck to all.

Translation into Spanish: Dieta de habre y olor corporal y halitosis

Amazon USA full linkhttp://www.amazon.com/gp/product/B00GIKLR6M/ref=as_li_ss_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B00GIKLR6M&linkCode=as2&tag=mri0a-20

Amazon USA shortened linkhttp://goo.gl/iisvYR

Amazon UK full linkhttp://www.amazon.co.uk/gp/product/B00GIKLR6M/ref=as_li_ss_tl?ie=UTF8&camp=1634&creative=19450&creativeASIN=B00GIKLR6M&linkCode=as2&tag=mere0d-21

Amazon UK shortened linkhttp://goo.gl/mH2ZyN

Or you can go through the Amazon links on either sidebar



María

María de la Torre
Founder and Executive Director

A Public Charity
maria.delatorre@meboresearch.org
www.meboresearch.org
www.mebo.com.br/ (em português)
MEBO's Blog (English)
El Blog de MEBO (español)


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