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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Monday, February 24, 2014

How to control body & breath odor in 2014?

Not everyone has the same cause of BO/BB, so the treatment to control odor is not always the same for everyone. Not everyone has TMAU, and some are more concerned with other types of FMO3 body odor also resulting in halitosis (bad breath), generalized body odor, vaginal odor, and/or bromhidrosis (underarm, external groin area, feet). Some of the causes of breath and body odor may be localized, like the dorsal tongue, tonsillitis, tonsilloliths, or bacteria on the feet, for example, these are things that your dentist, podiatrist, gynecologist, and/or medical doctor can help with.

However, most difficult-to-control odor comes from within. It usually originates in the intestinal flora. Some of the metabolic pathways (FMO3 and others) that could be deficient work with, but are not limited to, the metabolism of TMA, sulfur (hydrogen sulfide),
Image Aurametrix
(click on picture)
volatile fatty acids (scroll down to see all posts on short chair fatty acids), alcohols, auromatic ring compounds, sugars, dairy and others. See medical paper about the emerging role of H2S in the colon - 2003 paper, "Emerging role of hydrogen sulfide in colonic physiology and pathophysiology" suggesting H2S as human "gasotransitter." Unfortunately, there are limited tests available, such as the blood test for diabetes and the TMAU test. In addition, in some cases, the sufferer's metabolism may not be working well at metabolizing to a non-odorous state certain odorous chemicals that we get from food and drugs, see post “FMO3 Odor (not necessarily TMAU)." When we mention “drugs” we are referring to some (not all) prescription medications, over-the-counter medications, alcohol, marijuana, and street drugs. Also see PowerPoint presentation made for MEBO by Dr. Elizabeth Shephard, who is currently undergoing government funded research for a therapeutic for TMAU odor, "Pharmacogenetics & Personalized Medicine," and "FMO3 - a protein that can multi-task."

Your gastroenterologist can help look for digestive disorders that may be producing odor, such as H pylori or GERD, for example. Unfortunately, the existence of others test for odor conditions are unknown to our community. This is why the MEBO community around the world work so hard to pursue research, and the raising awareness campaign is very much a part of this pursuit.

RE DIET: Aside from the diabetic diet and diets recommended by gastroenterologists for digestive health, there really isn't any other diet published in professional journals specifically for odor conditions, other than the low choline diet for TMAU sufferers. Coincidentally, the low choline diet is also somewhat low in proteins and sulfur, so this diet also may help those sufferers whose gut flora may be producing too much odorous chemicals from these food sources or from medications. As we know, the human body needs protein, choline, fats (the good kind), and carbs (as opposed to simple sugars). Even if an attempt is made to completely eliminate any of these in everyday diet, eventually our bodies will scream out with strong, uncontrollable hunger urges for these foods; otherwise, we will become very ill and potentially die. So, the solution to successfully stay on a diet as a lifestyle change, food from these food groups need to be consumed. Therefore, in order to control odor, each sufferer would need to decrease the amount of the foods that produce body/breath odors while trying to consume food that keep us healthy and odor-free.





María de la Torre
Founder and Executive Director

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