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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Monday, September 26, 2016

More information on Grape Seed supplements and Resveratrol

Since not enough has been studied of the results of resveratrol in relation to body and/or breath odor conditions, I would like to add in this post a few more references to studies of resveratrol. Before I do, I would again like to stress the importance of consulting with your physician before taking any supplement, including Grape Seed supplements and Resveratrol. Below are some quotes noted on the bottles of these supplements.

CAUTION: Some sufferers have found that Resveratrol increases their blood pressure. Please check your blood pressure before and during taking resveratrol.

Studies indicate that resveratrol changes gut microbiome and inhibits trimethylamine (TMA) production by gut bacteria.

New Research Topics (2016):

  1. Resveratrol and health - A comprehensive review of human clinical trials
    Article (PDF Available) in Molecular Nutrition & Food Research 55(8):1129-41 · August 2011 with 1,188 Reads
    DOI: 10.1002/mnfr.201100143 · Source: PubMed

    Very few published human studies have explored the ability of resveratrol to achieve the physiological benefits that have been observed in laboratory models, although many clinical trials have recently been initiated. This review aims to examine the current state of knowledge on the effects of resveratrol on humans and to utilize this information to develop further guidelines for the implementation of human clinical trials.

    In the Summary and Recommendations of this study (see #12) it states,
    12 Summary and recommendations

    The emerging data from human clinical trials confirmswhat the past decade of in vitro and laboratory animalmodels have suggested; resveratrol has considerable poten-tial to improve health and prevent chronic disease inhumans. We believe the evidence is sufficiently strong toconclude that a single dose of resveratrol is able to inducebeneficial physiologic responses, and that either weeks ormonths of resveratrol supplementation produces physiolo-gic changes that are predictive of improved health, especiallyin clinical populations with compromised health...

  2. Targeting gut microbiome to fight heart disease Date: April 5, 2016 Source: American Society for Microbiology Summary: A compound found in red wine, resveratrol, reduces the risk of heart disease by changing the gut microbiome, according to a new study. Cardiovascular disease remains the leading cause of death in industrialized societies including the United States, and the incidence is growing in developing countries.
    … Resveratrol inhibits TMA production by gut bacteria... In our current study, we found that resveratrol can remodel the gut microbiota including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Prevotella, and increasing the relative abundance of Bacteroides, Lactobacillus, Bifidobacterium, and Akkermansia in mice," said Dr. Mi. "Resveratrol reduces TMAO levels by inhibiting the gut microbial TMA formation via remodeling gut microbiota.
  3. Therapeutic potential of resveratrol: the in vivo evidence
    Joseph A. Baur and David A. Sinclair
  4. Abstract | Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.

Please keep in mind that especially if you have tested negative for TMAU, what works for TMAU sufferers may not work for you at all if you don't have TMAU. Note that there has been no serious research on resveratrol's effects on body odor or even on general health with long-term use. If you think resveratrol may be causing you side effects, it is be best for you to discontinue using it and consult with your doctor.

CAUTION: Some sufferers have found that Resveratrol increases their blood pressure. Please check your blood pressure before and during taking resveratrol.

"Caution: Persons taking medications that affect platelet aggregation (such as aspirin, warfarin, NSAIDs) or persons with bleeding disorders, such as peptic ulcers should consult a healthcare professional before using grape seed extract."
Nature's Way Premium Extract Grape Seed vcaps

"Caution: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this [resveratrol] or any dietary supplement."
BRI Resveratrol Extra Strength

Possible "Side effects may include minor gastrointestinal upset, nausea, headache and fatigue and possible supplement-drug interactions with estrogens and anticoagulants."

Please always take heed when a sufferer tells you that a product or diet has not been research for body or breath odor conditions, or whether it has been researched ONLY for TMAU, a condition you might not have. It might not work for you. As far as I know, no halitosis or body odor expert has recommended resveratrol for these conditions. Therefore, MEBO does not recommend it either, but consideres it to be an interesting product worthy of further research in relation to halitosis and body odor.


María de la Torre
Founder and Executive Director

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Stephanie said...

Very curious to hear some personal accounts of resveratrol use. I just ordered some as well as a high potency probiotic.

Sep 27, 2016, 3:43:00 PM
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