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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Friday, September 30, 2016

Differences between DMB and RESVERATROL

DMB and Resveratrol both inhibit choline from being converted to odorous TMA by gut bacteria in a slightly different way. Resveratrol encourages good bacteria to flourish (Lactobacillus and Bifido). Resveratrol increased levels of the genera Lactobacillus and Bifidobacterium, which increased the bile salt hydrolase activity, thereby enhancing bile acid (BA) deconjugation and fecal excretion,

… Resveratrol inhibits TMA production by gut bacteria... In our current study, we found that resveratrol can remodel the gut microbiota including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Prevotella, and increasing the relative abundance of Bacteroides, Lactobacillus, Bifidobacterium, and Akkermansia in mice," said Dr. Mi. "Resveratrol reduces TMAO levels by inhibiting the gut microbial TMA formation via remodeling gut microbiota.
CAUTION: Some sufferers have found that Resveratrol increases their blood pressure. Please check your blood pressure before and during taking resveratrol.
Opinion: It may not be coincidence that DMB and Resveratrol are both found in grapes (eg wine), but grape extract has a ton of chemicals in it. DMB is just one weak one, and an alcohol.

One could still debate that Resveratrol acting like a prebiotic or probiotic in shifting gut flora may be bad for you- but then one would also have to argue that any fermented food or probiotic is also harmful -- or even meat is harmful because it also shifts gut flora. At least there is a study with Resveratrol which proposes which gut flora species it shifts to, unlike most/many other gut flora changers. But for TMAU, the proposed theory behind Resveratrol is what we have been looking for, second to an FMO3 booster, which is going to take years to get through the Trinzyme research study, which is ready for clinical trials stage pending funding.

Please keep in mind that especially if you have tested negative for TMAU, what works for TMAU sufferers may not work for you at all if you don't have TMAU. Note that there has been no serious research on resveratrol's effects on body odor or even on general health with long-term use. If you think resveratrol may be causing you side effects, it is be best for you to discontinue using it and consult with your doctor.

CAUTION: Some sufferers have found that Resveratrol increases their blood pressure. Please check your blood pressure before and during taking resveratrol.

"Caution: Persons taking medications that affect platelet aggregation (such as aspirin, warfarin, NSAIDs) or persons with bleeding disorders, such as peptic ulcers should consult a healthcare professional before using grape seed extract."
Nature's Way Premium Extract Grape Seed vcaps

"Caution: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this [resveratrol] or any dietary supplement."
BRI Resveratrol Extra Strength

Possible "Side effects may include minor gastrointestinal upset, nausea, headache and fatigue and possible supplement-drug interactions with estrogens and anticoagulants."

Please always take heed and beware when a sufferer tells you that a product or diet has not been research for body or breath odor conditions, or whether it has been researched ONLY for TMAU, which you might not have. It might not, and probably will not, work for you. As far as I know, no halitosis or body odor expert has recommended resveratrol for these conditions, and therefore, MEBO does not recommend it either. It is an interesting product worthy of further research in relation to halitosis and body odor.


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