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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
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UK residents survey : Prof Shephard/MEBO (until 31/1/21) click to visit survey
click to Read more/less

Prof Elizabeth Shephard is conducting a TMAU fact-finding survey for UK RESIDENTS. She plans to use it to raise awareness with decision-makers, such as perhaps MPs. It closes 31 Jan 21.

who is the survey intended for ?
UK residents who identify with TMAU

Living with TMAU study

We invite you to participate in a research project entitled ‘Living with TMAU’.

click to visit survey

survey full url :
https://meboresearch.co.uk/index.php/living-with-tmau-lwtmau-study/

Participation in the project will involve completion of a short questionnaire, which aims to capture the experiences of those living with the condition. There are two questionnaires.

For individuals with TMAU over the age of 18

For a parent or guardian of a child with TMAU.

The results from the questionnaires will be compiled to produce a report that will be available for you to use, for example, to lobby your MP. The findings will be used to reach out to policy makers in the UK to have TMAU recognised as an invisible disability and to make people aware of what it is like to live with the disorder. The report will be made available on the MEBO, UK website.

To complete either questionnaire you must be over 18 and resident in the UK. The questionnaire responses are anonymous and no personal identifiers will be collected.

The questionnaire closes 11:59 pm (GMT) Sunday 31st January 2021.

MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Friday, September 30, 2016

Differences between DMB and RESVERATROL


DMB and Resveratrol both inhibit choline from being converted to odorous TMA by gut bacteria in a slightly different way. Resveratrol encourages good bacteria to flourish (Lactobacillus and Bifido). Resveratrol increased levels of the genera Lactobacillus and Bifidobacterium, which increased the bile salt hydrolase activity, thereby enhancing bile acid (BA) deconjugation and fecal excretion,

… Resveratrol inhibits TMA production by gut bacteria... In our current study, we found that resveratrol can remodel the gut microbiota including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Prevotella, and increasing the relative abundance of Bacteroides, Lactobacillus, Bifidobacterium, and Akkermansia in mice," said Dr. Mi. "Resveratrol reduces TMAO levels by inhibiting the gut microbial TMA formation via remodeling gut microbiota. https://www.sciencedaily.com/releases/2016/04/160405105547
htm http://www.eurekalert.org/pub_releases/2016-04/asfm-ttg033116.php
CAUTION: Some sufferers have found that Resveratrol increases their blood pressure. Please check your blood pressure before and during taking resveratrol.
Opinion: It may not be coincidence that DMB and Resveratrol are both found in grapes (eg wine), but grape extract has a ton of chemicals in it. DMB is just one weak one, and an alcohol.

One could still debate that Resveratrol acting like a prebiotic or probiotic in shifting gut flora may be bad for you- but then one would also have to argue that any fermented food or probiotic is also harmful -- or even meat is harmful because it also shifts gut flora. At least there is a study with Resveratrol which proposes which gut flora species it shifts to, unlike most/many other gut flora changers. But for TMAU, the proposed theory behind Resveratrol is what we have been looking for, second to an FMO3 booster, which is going to take years to get through the Trinzyme research study, which is ready for clinical trials stage pending funding.

Please keep in mind that especially if you have tested negative for TMAU, what works for TMAU sufferers may not work for you at all if you don't have TMAU. Note that there has been no serious research on resveratrol's effects on body odor or even on general health with long-term use. If you think resveratrol may be causing you side effects, it is be best for you to discontinue using it and consult with your doctor.


CAUTION: Some sufferers have found that Resveratrol increases their blood pressure. Please check your blood pressure before and during taking resveratrol.

"Caution: Persons taking medications that affect platelet aggregation (such as aspirin, warfarin, NSAIDs) or persons with bleeding disorders, such as peptic ulcers should consult a healthcare professional before using grape seed extract."
Nature's Way Premium Extract Grape Seed vcaps

"Caution: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this [resveratrol] or any dietary supplement."
BRI Resveratrol Extra Strength

Possible "Side effects may include minor gastrointestinal upset, nausea, headache and fatigue and possible supplement-drug interactions with estrogens and anticoagulants."

Please always take heed and beware when a sufferer tells you that a product or diet has not been research for body or breath odor conditions, or whether it has been researched ONLY for TMAU, which you might not have. It might not, and probably will not, work for you. As far as I know, no halitosis or body odor expert has recommended resveratrol for these conditions, and therefore, MEBO does not recommend it either. It is an interesting product worthy of further research in relation to halitosis and body odor.

María

María de la Torre
Founder and Executive Director

A Public Charity
maria.delatorre@meboresearch.com
www.meboresearch.org
www.mebo.com.br/
MEBO's Blog (English)
El Blog de MEBO (español)

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