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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Friday, April 14, 2017


Irene Gabashvili, Ph.D.
March 31, 2017


“What if very minor faults in your enzymes and slightly imbalanced microbes in your body
turn your life into a social nightmare?
Tune in to hear about our research.”

These comparisons consistently indicated a significant difference between the results of persons who suffered from body odor and/or halitosis and that of the control group.
In 2009 thru 2012, MEBO Research did an exploratory study, 'Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis' under the direction of MEBO’s Scientific Director, Irene Gabashvili, Ph.D., with the Biolab Medical Unit UK. This study initially started as a Gut Dysbiosis Study, but as the results came in, Dr. Gabashvili determined that they were more useful as a potential screening tool for breath/body odor analysis. All participants were from the United Kingdom, and significant data was acquired from this study.

NCT02692495 - Completed 
United Kingdom 2009-2012

On February 17, 2016, MEBO Research, Inc. received approval for the MEBO Exploratory Study, ‘Relationships Between Malodor and Urine Metabolomics.’

We appreciate Irene's pro bono services through the years since 2009.
Irene Gabashvili is representing MEBO as the registered U.S. Principal Investigator for both these studies. She is currently collaborating with the registered Principal Investigator, David Wishart, PhD, of the Metabolomics Innovation Centre (TMIC) of the University of Alberta, in Edmonton, Canada in the currently active study. All participants for the Pilot Study reside in Canada.

We will eventually need to do some fundraising for her to publishing these studies in a reputable scientific journal for MEBO.
On March 24th, 2017, MEBO received the initial set of results of the Pilot Study, and Irene created a PowerPoint presentation of both studies’ results. Very interesting observations were made in the comparison of the results of the participants who suffer from breath and/or body odor with the controls.The lab used a total of 96 metabolites of different classes (amino acids, biogenic amines, acylcarnitines, glycerophospholipids, sphingolipids) are identified and quantified and the results were also compared for lipids.

These comparisons consistently indicated a significant difference between the results of persons who suffered from body odor and/or halitosis and that of the control group.
  As a result of the interesting data, both Drs. David Wishart and Irene Gabashvili are in agreement that the Metabolomic Profiling Study should continue with additional analysis of the current samples and with further interviews of the participants.

Irene Gabashvili tells us that we are now need to obtain more data before we send the participants their results. She tells us,

At this stage, I plan to start a survey to collect more data from the Canadian participants and others - like usual diet, all kinds of tests that came positive in the past like TSH, CBC, metabolic panel, etc; genomic & metabolomic data, exact symptoms...
We are all very excited with the potential of this study in hopes that we obtain much more data for Irene to analyze in an effort to find patterns and solutions. We appreciate Irene's pro bono services through the years since 2009. We will eventually need to do some fundraising for her to publishing these studies in a reputable scientific journal for MEBO. We need to do this in order to further give validation the study, and thus hopefully, to obtain research grants to fund this research moving forward.


María de la Torre
Founder and Executive Director

A Public Charity
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Anonymous said...

I would have been a participant in the original study. If I understand correctly, further data is only required from those (Canadian) participants in the most recent study. If there is a need to extend this to those UK/IRL people from the previous study, I'd be quite happy to participate.

(It's probably pointless to volunteer specific data as there clearly has to be a methodology to investigating this disorder ...but I can't help myself so I'll say it anyway! I've recently undergone a series of medical investigations for elevated liver enzymes - to include multiple blood tests, ultrasound examination and liver biopsy (there's very little indication of actual damage although the biopsy did show evidence of inflammation). Of course, there are numerous causes of same but all the usual culprits have been ruled out over a course of 6 weeks or so. Probably not connected - but I just wanted to put it out there just in case it resonates with anyone else).

Apr 17, 2017, 6:06:00 PM
Aurametrix said...

Thank you, it's very useful! If you think of something else, please use the form:

Apr 24, 2017, 1:00:00 AM
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