MEBO awarded a study grant from UBIOME

MEBO has been awarded a grant from Ubiome.
It was awarded via the Ubiome Academic Grant Program.
The award means a study can be done with a number of free Ubiome kits.
It will explore the MICROBIOME using the Ubiome stool test.

An outline of a potential study was put forward to Ubiome by MEBO's Prof Irene Gabashvili and accepted :
This involved 30 volunteers getting 2 Ubiome stool test kits.

"The proposed study would identify microbial communities associated with flare ups and remissions of systemic malodor".

This will now include 'People are allergic to me' (PATM).

Talks are underway about formatting a study.

Some ideas that have been discussed :

Ubiome offered to make it 3 tests per person.

The current Ubiome stool test is bacteria only, and does not include fungus (e.g. candida). Ubiome will look to include candida (albicans ?).

It will also be asked if they could include small parasite microbes.;

Planning the study is at a very early stage. One big question is how to identify between remission and flare-ups, as many cannot smell themselves so cannot monitor their condition.

Prof Gabashvili blog post and survey

Irene has begun formulating a questionaire; for the study, and has wrote a post on the Aurametrix website on the study.

Prof Gabashvili Aurametrix post on the study : link

Currently the survey is for discussion purposes only (not to be filled in).

This is early formulation of a study with discussions with Ubiome.

It should be kept in mind it has many limitations, not least due to the early stages of microbiome knowledge and testing, as well as cost. and being limited to this test only.

Ideas and comments are welcome.

Excerpt from original proposal put forward by Prof Gabashvili and accepted :

Summary

The proposed study would identify microbial communities associated with flare ups and remissions of systemic malodor.

Background

Human odorprints, mostly owing to the microbiome, have proven their value as biomarkers of health

and environmental exposures.

In recent years, microbial networks responsible for localized malodors (e.g., halitosis [1,2] and axillary

odor [3,4]) have been mapped by using next generation sequencing approaches.

Intestinal microbes responsible for psychologically debilitating systemic malodor (whole-body and

extraoral halitosis), however, remain to be identified. Even a relatively straightforward disorder of

choline metabolism trimethylaminuria (TMAU) is thought to exhibit complex host-gene microbiome

interactions [5] and has not been sufficiently studied.

Mapping gut microbiome is needed to understand human metabolic disfunction, make proper dietary

recommendations and develop targeted treatments such as microbial therapies [6-8]. Our preliminary

analysis of culture-, PCR- and 16S-RNA-based data found several Operational Taxonomic Units (OTUs)

potentially linked to systemic malodor. Proposed controlled pilot study will provide a more

comprehensive evaluation and, combined with our prior data [9-12], will help to develop new therapies and treatments.

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