Admin Control Panel

New Post | Settings | Change Layout | Edit HTML | Edit posts | Sign Out

MEBO - UBIOME study 2018

NCT03582826
ClinicalTrials.gov
MEBO Gut Microbiome Study
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Ubiome Gut EXPLORER : 10% OFF
Join/Watch the weekly
TMAU UP Podcasts

Videos : TMAU stories

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact map@meboresearch.org
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
BannerFans.com
RESEARCH DETAILS

DONATIONS THRU 31-NOV-2016:
£ 943.03/GBP
$ 568.00/USD

TOTAL at today's ROE
£0.80/GBP = $1.00/USD

£1,398.07 = $1,745.14

MEBO UK PAYPAL FOR TRINZYME

********
MEBO US PAYPAL FOR TRINZYME

Your currency will be automatically converted to USD or GBP by PayPal.

Option: pay with your credit card instead of PayPal account by clicking on either Donate button above.

Popular Posts (last 30 days)

Upcoming get-togethers


Let us know if you want a meetup listed

Subscribe to Blog

Enter your email address:

Delivered by FeedBurner

You will be sent a verification email

Subscribe in a reader

Blog Archive

Tuesday, May 8, 2018

MEBO awarded a study grant from UBIOME

MEBO has been awarded a grant from Ubiome.
It was awarded via the Ubiome Academic Grant Program.
The award means a study can be done with a number of free Ubiome kits.
It will explore the MICROBIOME using the Ubiome stool test.

An outline of a potential study was put forward to Ubiome by MEBO's Prof Irene Gabashvili and accepted :
This involved 30 volunteers getting 2 Ubiome stool test kits.

"The proposed study would identify microbial communities associated with flare ups and remissions of systemic malodor".
This will now include 'People are allergic to me' (PATM).

Talks are underway about formatting a study.

Some ideas that have been discussed :
Ubiome offered to make it 3 tests per person.
The current Ubiome stool test is bacteria only, and does not include fungus (e.g. candida). Ubiome will look to include candida (albicans ?).
It will also be asked if they could include small parasite microbes.;

Planning the study is at a very early stage. One big question is how to identify between remission and flare-ups, as many cannot smell themselves so cannot monitor their condition.

Prof Gabashvili blog post and survey
Irene has begun formulating a questionaire; for the study, and has wrote a post on the Aurametrix website on the study.
Prof Gabashvili Aurametrix post on the study : link
Currently the survey is for discussion purposes only (not to be filled in).

This is early formulation of a study with discussions with Ubiome.
It should be kept in mind it has many limitations, not least due to the early stages of microbiome knowledge and testing, as well as cost. and being limited to this test only.
Ideas and comments are welcome.

Excerpt from original proposal put forward by Prof Gabashvili and accepted :

Summary
The proposed study would identify microbial communities associated with flare ups and remissions of systemic malodor.

Background
Human odorprints, mostly owing to the microbiome, have proven their value as biomarkers of health
and environmental exposures.
In recent years, microbial networks responsible for localized malodors (e.g., halitosis [1,2] and axillary
odor [3,4]) have been mapped by using next generation sequencing approaches.
Intestinal microbes responsible for psychologically debilitating systemic malodor (whole-body and
extraoral halitosis), however, remain to be identified. Even a relatively straightforward disorder of
choline metabolism trimethylaminuria (TMAU) is thought to exhibit complex host-gene microbiome
interactions [5] and has not been sufficiently studied.
Mapping gut microbiome is needed to understand human metabolic disfunction, make proper dietary
recommendations and develop targeted treatments such as microbial therapies [6-8]. Our preliminary
analysis of culture-, PCR- and 16S-RNA-based data found several Operational Taxonomic Units (OTUs)
potentially linked to systemic malodor. Proposed controlled pilot study will provide a more
comprehensive evaluation and, combined with our prior data [9-12], will help to develop new therapies and treatments.


get New Posts by EMAIL : Enter your email address :



A EURORDIS and NORD Member Organization

0 comments:

Post a Comment