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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Tuesday, May 8, 2018

MEBO awarded a study grant from UBIOME

MEBO has been awarded a grant from Ubiome.
It was awarded via the Ubiome Academic Grant Program.
The award means a study can be done with a number of free Ubiome kits.
It will explore the MICROBIOME using the Ubiome stool test.

An outline of a potential study was put forward to Ubiome by MEBO's Prof Irene Gabashvili and accepted :
This involved 30 volunteers getting 2 Ubiome stool test kits.

"The proposed study would identify microbial communities associated with flare ups and remissions of systemic malodor".
This will now include 'People are allergic to me' (PATM).

Talks are underway about formatting a study.

Some ideas that have been discussed :
Ubiome offered to make it 3 tests per person.
The current Ubiome stool test is bacteria only, and does not include fungus (e.g. candida). Ubiome will look to include candida (albicans ?).
It will also be asked if they could include small parasite microbes.;

Planning the study is at a very early stage. One big question is how to identify between remission and flare-ups, as many cannot smell themselves so cannot monitor their condition.

Prof Gabashvili blog post and survey
Irene has begun formulating a questionaire; for the study, and has wrote a post on the Aurametrix website on the study.
Prof Gabashvili Aurametrix post on the study : link
Currently the survey is for discussion purposes only (not to be filled in).

This is early formulation of a study with discussions with Ubiome.
It should be kept in mind it has many limitations, not least due to the early stages of microbiome knowledge and testing, as well as cost. and being limited to this test only.
Ideas and comments are welcome.

Excerpt from original proposal put forward by Prof Gabashvili and accepted :

The proposed study would identify microbial communities associated with flare ups and remissions of systemic malodor.

Human odorprints, mostly owing to the microbiome, have proven their value as biomarkers of health
and environmental exposures.
In recent years, microbial networks responsible for localized malodors (e.g., halitosis [1,2] and axillary
odor [3,4]) have been mapped by using next generation sequencing approaches.
Intestinal microbes responsible for psychologically debilitating systemic malodor (whole-body and
extraoral halitosis), however, remain to be identified. Even a relatively straightforward disorder of
choline metabolism trimethylaminuria (TMAU) is thought to exhibit complex host-gene microbiome
interactions [5] and has not been sufficiently studied.
Mapping gut microbiome is needed to understand human metabolic disfunction, make proper dietary
recommendations and develop targeted treatments such as microbial therapies [6-8]. Our preliminary
analysis of culture-, PCR- and 16S-RNA-based data found several Operational Taxonomic Units (OTUs)
potentially linked to systemic malodor. Proposed controlled pilot study will provide a more
comprehensive evaluation and, combined with our prior data [9-12], will help to develop new therapies and treatments.

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