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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country
MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Tuesday, August 20, 2019

Epulopiscium bacteria in odor conditions

https://aurametrix.com/blog/balance.html

NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM) 
United States 2018 - ongoing

...this is not the only responsible microorganism for odors or PATM. We will be reporting more, along with what seem to help in reducing the levels.
Although Irene is still waiting for the final results of the 4th batch of participants from uBiome, she has been analyzing all the gut microbiome results she has received so far. A significant finding that applies only to some of the participants with odor conditions is a group of Gram-positive bacteria found at high levels on sufferers who have very strong odor. This unusually large size, or “giant” bacteria has the genus name of Epulopiscium, and is more commonly found in the gut of brown surgeonfish.

Irene Gabashvili, PhD., MEBO Scientific Director and Principle Investigator of the study, wrote a post in her Aurametrix Blog, "The Delicate Balance, NCT03582826" about this finding in which she states:


Epulopiscium was found in only 5% of general population that tested with uBiome. But we see a much higher percentage of these bacteria in our samples, depending on the symptoms reported.

It could be as high as 50% in the sufferers experiencing the worst symptoms, decreasing as symptoms lessen...

Of course, this is not the only responsible microorganism for odors or PATM. We will be reporting more, along with what seem to help in reducing the levels.

We will also tell about bacteria "neutralizing" the odors, found in remission. Some of them are antiinflammatory, others help with digestion.
https://aurametrix.com/blog/balance.html

Irene Gabashvili, PhD., is our MEBO Scientific Director and Principal Investigator of the MEBO Gut Microbiome Study sponsored by a uBiome Grant.

For additional reading on the Epulopiscium fishelsoni, see article in the New York Times, March 18, 1993, Section D, Page 22, original in the British journal, Nature.


Pulverizing the genetic material from the bacteria, the researchers then multiplied the DNA into millions of copies through the use of a technique called polymerase chain reaction. They next compared the genes with those from many other known prokaryotes and eukaryotes and demonstrated that E. fishelsoni is a true bacterium, a member of the microbial family that includes the botulism pathogen.
https://www.nytimes.com/1993/03/18/us/in-the-world-of-bacteria-a-behemoth.html

To see all posts in this blog on the MEBO Gut Microbiome Study, scroll down and click on 'Older Posts' on this link, http://www.meboblog.com/search/label/MEBO%20Gut%20Microbiome%20Study

María


María de la Torre
Founder and Executive Director

A Public Charity
maria.delatorre@meboresearch.com
www.meboresearch.org
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A EURORDIS and NORD Member Organization

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