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MEBO Gut Microbiome Study
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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Friday, August 23, 2019

DHA fish oil suppresses TMA production

Odor is NOT produced by choline, but rather by TMA producing gut bacteria after the bacteria feasts on choline in the diet.
A study conducted by the College of Food Science and Engineering, Ocean University of China, suggests that fish oil affects the metabolic process of trimethylamine N-oxide (TMAO) precursor, trimethylamine (TMA), through TMA production and flavin-containing mkonooxygenase (FMO) activity in mice. A paper on this study was published in the Royal Society of Chemistry, DOI: 10.1039/C7RA10248H (Paper) RSC Adv., 2017, 7, 56655-56661.

This study suggests that the benefits of DHA-enriched fish oil are:

  1. Increases choline levels in the blood, which is a healthy thing. Choline is an essential nutrient and in itself does not produce odor. Odor occurs only when gut bacteria takes up choline in the gut and produces odorous trimethylamine (TMA) that goes to the bloodstream.
  2. Suppresses production of TMA by gut bacteria
  3. Accelerates FMO metabolic process of TMAO formation

Excerpts from the Abstract:

Fish oil as a commercial functional food has various positive effects on human health...Plasma choline, trimethylamine (TMA), and TMAO pharmacokinetics were measured after treatment with choline chloride through oral gavage or trimethylammonium chloride by intraperitoneal injection. The mRNA expressions and activities of hepatic flavin-containing monooxygenases (FMOs) were also determined. Results showed that fish oil increased choline circulation levels in plasma, while suppressing the production of TMA and raising the concentration–time curve (AUC) of TMAO according to pharmacokinetic parameters. Further analysis indicated that up-regulated FMO gene expression levels and activities accelerated the metabolic process of TMAO when administrating plenty of TMAO precursors. The above results demonstrated that long-term supplementation with DHA-enriched fish oil could regulate the metabolic process of TMAO in vivo, which provides references for the development of nutritional supplements.

College of Food Science and Engineering, Ocean University of China

"Docosahexaenoic acid (DHA) is an omega-3 fatty acid...naturally produced in small quantities by our bodies, but to achieve adequate amounts, DHA needs to be taken in through dietary sources such as cold-water fish, grass-fed meat, and dairy, and omega-3 enriched or pasture-raised eggs. It is also available as supplements, such as fish oil."

Since choline is an essential nutrient, it is beneficial for health to have a good level of choline in the blood, while somehow preventing gut bacteria from "stealing" our choline.
Since a low choline diet is recommended as an odor-management protocol for trimethylaminuria (TMAU), there may be a misinterpretation about whether odorless choline itself produces odor. It does not. Instead, TMA producing gut bacteria feeds on the choline we eat to produce odorous TMA, which then enters the bloodstream. TMA production by gut bacteria can be better understood when seen as the microbial version of "poop". Odor is NOT produced by choline, but rather by TMA producing gut bacteria after the bacteria feasts on choline in the diet.

Since choline is an essential nutrient, it is beneficial for health to have a good level of choline in the blood, while somehow preventing gut bacteria from "stealing" our choline. The danger to health is when sufferers go on a low choline diet and gut bacteria then "steals" the small amount of choline in the diet, thus creating a dangerously low level of choline in the blood:

A study published in NCBI, 'Choline Metabolism Provides Novel Insights into Non-alcoholic Fatty Liver Disease and its Progression', discusses choline's effects on liver function, "elucidating why non-alcoholic fatty liver disease (NAFLD) occurs and progresses sometimes to hepatocarcinogenesis."

In sum, this study suggests that DHA-enriched fish oil not only blocks gut bacteria to some degree from taking up choline in the diet, but it also causes accelerated FMO activity in the liver. As a result, odorous TMA is metabolized into odorless TMAO at a more efficient rate. Thus, it increases choline circulation levels in the blood. This is all very beneficial to TMAU sufferers.


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Anonymous said...

This is such a simple thing now that we know it. One has to ask, with all the research, money and frustration that has gone into finding a cure--well, it's ironic to say the least.

Aug 24, 2019, 2:49:00 AM
Anonymous said...

Fish oil makes me smell.

Aug 25, 2019, 2:32:00 PM
Anonymous said...

It's important to use a good brand of fish oil, as I found out after doing research on Google. Some have more additives and less DHA than others. Also, the question arises: would other types of omega-3 oils with high DHA levels be as effective? Again, it involves doing some hunting on Google.

Aug 29, 2019, 3:42:00 AM
Anonymous said...

any info on fish oil pills with high DHA?

Dec 13, 2019, 2:09:00 PM
Anonymous said...

Hi guys n girls,

Anyone on here had good results using dha fish oil?

Sounds a bit fishy lol but seriously I really hope that it does work for all of us!

Jan 20, 2020, 2:01:00 PM
Anonymous said...

I was wondering the same thing as I found some vegan oil from algae which is high in dha.
If fish oil makes some people stink maybe this algae oil won't?

Jan 20, 2020, 2:05:00 PM
Anonymous said...

I have not seen any change as of yet. I have taken fish oil for about 3 weeks.

Jan 24, 2020, 9:05:00 AM
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