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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
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"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
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survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Monday, May 18, 2020

anti-TMA pill could be a year or 2 ?

Podcast March 2020
Dr Stanley Hazen of Cleveland Clinic discusses the TMAO-CVD theory

The Hazen Cleveland lab team put forward the TMAO-Hypothesis in 2011, and have been looking at ways to inhibit trimethylamine formation in the gut (as well as other things).

In this March podcast, Dr Hazen says (quote ... roughly) :
1. DMB inhibited TMA formation in gut by about 98% (they are using other stronger inhibitors now it seems).
2. Human trials will begin in 2020.

Dr Hazen also says (something like)
"now whether it will be commercially available this year, I don't know".

From that you could wonder that the Procter & Gamble anti-TMA pill might be available to buy in the near future ... say a year or 2 or 3 ?
It will be available to buy over-the-counter.

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Anonymous said...

Would it be possible to have another company make a pill combining pure resveratrol with DMB and market that on a small scale to TMAU sufferers?

May 19, 2020, 3:52:00 AM
Maria de la Torre, Founder and Executive Director, MEBO Research said...

Keep in mind that the human trial phase is for cardiovascular disease, not for TMAU patients. Repurposing this product for TMAU has not been researched yet.

May 19, 2020, 1:58:00 PM
Maria de la Torre, Founder and Executive Director, MEBO Research said...

Anonymous, any company can sell DMB once it has satisfied the FDA research requirements.

Regarding Dr. Hazen's product, I don't know if it only has DMB or what other ingredients it may have. I believe it has been patented, so no other company can reproduce it exactly the same, and no other company that I know of would have researched it as thoroughly as Dr. Hazen's lab has these past few years.

May 19, 2020, 2:03:00 PM
Maria de la Torre, Founder and Executive Director, MEBO Research said...

Sell all posts in this blog on DMB:

May 19, 2020, 2:04:00 PM
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