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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
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"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
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Started May 2018 - Ongoing

Current people sent kits : 100/100
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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Monday, May 18, 2020

anti-TMA pill could be a year or 2 ?

Podcast March 2020
Dr Stanley Hazen of Cleveland Clinic discusses the TMAO-CVD theory

The Hazen Cleveland lab team put forward the TMAO-Hypothesis in 2011, and have been looking at ways to inhibit trimethylamine formation in the gut (as well as other things).

In this March podcast, Dr Hazen says (quote ... roughly) :
1. DMB inhibited TMA formation in gut by about 98% (they are using other stronger inhibitors now it seems).
2. Human trials will begin in 2020.

Dr Hazen also says (something like)
"now whether it will be commercially available this year, I don't know".

From that you could wonder that the Procter & Gamble anti-TMA pill might be available to buy in the near future ... say a year or 2 or 3 ?
It will be available to buy over-the-counter.

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Anonymous said...

Would it be possible to have another company make a pill combining pure resveratrol with DMB and market that on a small scale to TMAU sufferers?

May 19, 2020, 3:52:00 AM
Maria de la Torre said...

Keep in mind that the human trial phase is for cardiovascular disease, not for TMAU patients. Repurposing this product for TMAU has not been researched yet.

May 19, 2020, 1:58:00 PM
Maria de la Torre said...

Anonymous, any company can sell DMB once it has satisfied the FDA research requirements.

Regarding Dr. Hazen's product, I don't know if it only has DMB or what other ingredients it may have. I believe it has been patented, so no other company can reproduce it exactly the same, and no other company that I know of would have researched it as thoroughly as Dr. Hazen's lab has these past few years.

May 19, 2020, 2:03:00 PM
Maria de la Torre said...

Sell all posts in this blog on DMB:

May 19, 2020, 2:04:00 PM
Anonymous said...

Are there any update on this?

May 27, 2023, 2:55:00 PM
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