Mexico TMAO paper : TMAO & NASH in diabetes

new Mexico paper on TMA-oxide

aim :

What are the TMAO and Choline levels in Diabetes patient group ?

result :

Higher TMAO and low choline in type2 diabetes group ?

Serum TMAO, choline, betaine and bile acid levels were measured in 357 Mexican obese patients with different grades of NAFLD as determined by liver histology. Associations of NAFLD with TMAO, choline and betaine levels were tested. Moreover, association of TMAO levels with non-alcoholic steatohepatitis (NASH) was tested separately in patients with and without T2D.

Results: TMAO and choline levels were significantly associated with NAFLD histologic features and NASH risk. While increased serum TMAO levels were significantly associated with NASH in patients with T2D, in non-T2D subjects this association lost significance after adjusting for sex, BMI and insulin resistance. Moreover, circulating secondary bile acids were associated both with increased TMAO levels and NASH.

https://pubmed.ncbi.nlm.nih.gov/32791310/

These papers will keep popping up due to the TMAO-CVD 2011 theory by Hazen et al.

Around the world medic research groups will look to see if TMAO is connected to other disorders.

The papers on their own may not have much impact, and no-one will follow up.

It seems highly plausible TMA-dysbiosis will be associated with fatty liver due to the TMA-bacteria eating choline (choline being very important fatty liver prevention nutrient).

But no labs currently researching it in a sensible way.

e.g.

Are sub-par FMO3  people prone to NAFLD due to choline being eaten by TMA-bacteria ?

Are sub-FMO3 people prone to TMA-dysbiosis ?

  

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