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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
rareconnect.org TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Sunday, November 28, 2021

TMA the inflammation baddie ? TMAO a goodie ??

2 big FMO3-smell related stories recently :

1 : new study : TMA is the inflammation baddie and not TMAO ???
2. small Messina Italy lab looking at whether FMO3 common haplotypes with ma currently regarded harmless etc may affect FMO3 function in combination (readers say yes ??)

This post will look at the 'TMA-bad' recent study by Quadram Institute, Norwich, England

Note : paper details not fully absorbed. post may have errors.

Theory of paper :  in mice models, TMA caused blood-brain barrier inflammation, whereas TMAO was protective !!
This seems to contradict the TMAO-CVD theory put forward by Cleveland Clinic scientists in 2011.

That said, they are looking at at the blood-brain barrier, whereas Cleveland's theory is about blood vessel internal damage (blood vessels to heart etc). So both could be right (???). 
This paper seems to have been funded by an Alzheimers charity.

Group behind the study :
Quadram Institute UK is based around microbiome research etc. Seems to be quite well funded, probably by Government.
Microbiome research seems to have given us little useful info up until now. Possibly this is still the way their research is going.

Tweets same to suggest it was a 'eureka' wild research guess from a scientist based there.
The online fecal body odor forums are probably decades ahead of them in this type of study thinking. 
The idea for the study seems to be of Profs Lesley Hoyles and Simon McArthur.

How will this affect FMO3-smelly people ?
Probably win-win either way. Whether its TMA or TMAO they try to block, doesn't matter as they will both likely block TMA. For TMA to be the baddie would be preferable, as it means it's the main target for big pharmas, but TMAO as a target likely means blocking TMA anyway.
In theory it means TMA people are meant to be more prone to CVD etc, but 1 opinion is neither TMA or TMAO are much important re CVD but pharma-fanaticism about TMA/TMAO is very welcome. Perhaps TMA makes more sense, but who knows about either. Maybe TMA is just a sign of dysbiosis.

Details on the paper :

Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide
Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodriguez-Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L. Carvalho, Simon R. Carding, Michael Müller, Robert C. Glen, David Vauzour & Simon McArthur 

 
"Here, we use an integrated in vitro/in vivo approach to show that physiologically relevant concentrations of the dietary methylamine trimethylamine N-oxide (TMAO) enhanced blood-brain barrier (BBB) integrity and protected it from inflammatory insult, acting through the tight junction regulator annexin A1. In contrast, the TMAO precursor trimethylamine (TMA) impaired BBB function and disrupted tight junction integrity. Moreover, we show that long-term exposure to TMAO protects murine cognitive function from inflammatory challenge, acting to limit astrocyte and microglial reactivity in a brain region-specific manner."


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A EURORDIS and NORD Member Organization

2 comments:

Anonymous said...

Didn't the Moderna covid shot go directly to the cells and give the cells the instructions on what chemical to produce.

Can this same technology be used to bypass bad genes and go directly to the cell and make cells produce fmo3?


Nov 29, 2021, 12:15:00 AM
Aurametrix said...

The mRNA is degraded within a few days - so it it was coding for a functional FMO3 protein, the infusion of FMO# will be temporary. Vaccines are temporarily injecting something they want the body to develop immunity against - for example, a research vaccine against obesity makes the body to produce immunoglobulin G antibodies against the appetite hormone ghrelin.

Dec 5, 2021, 5:48:00 PM
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