TRIMETHYLAMINURIA TESTING LABS AROUND THE WORLD
All rates are subject to change. Please check with provider
(Site under construction: Last update 07 October 2011. If you know of any other TMAU test center, or if the information below needs updating, please contact us know at info@meboresearch.org)
CURRENT TMAU URINE TEST PROTOCOLS AND REFERENCE RANGES OF KNOWN TMAU TEST LABS (Subject to change)
Orphanet offers a listing of labs in Europe that have TMAU Testing Programs.
MEBO RESEARCH INTERNATIONAL TEST PROGRAM
COUNTRY : UNITED STATES (Test available to all sufferers throughout the world via UPS or FedEx)
MEBO/ TMAU URINE TEST PROGRAM
MEBO Research International
TMAU Test Program Application
Results given consistent with
Primary (genetic) TMAU
or Secondary (acquired) TMAU
results sent by email
TMAU phenotype (urine) test$150 for 1 sample plus shipping costs
(arranged via UPS)
Test analysis will normally occur in batches of 15
COUNTRY : UNITED KINGDOM LAB : Sheffield Children's Hospital, Department of Clinical Chemistry LOCATION : Sheffield, England; Persons outside the UK can test TYPE OF TESTING AND INSTRUCTIONS : Urine (phenotype) testing; Checks for TMA & TMAO; Reference range (normal) " TMA <10.9; TMA/TMAO ratio <0.21 CONTACT DETAILS : Nigel Manning,, Principal Clinical Scientist, Dept. Clinical Chemistry, Sheffield Children's Hospital; email: Nigel.Manning@sch.nhs.uk COST : Free on NHS, Must be referred through GP COST AND WAYS TO TEST : Best option is to give your physician the letter and TMAU information linked below from Nigel Manning, Principal Scientist, Sheffield Hospital. Nigel welcomes emails or phone calls from physicians:
COUNTRY : AUSTRALIA LAB :Royal Children's Hospital (RCH) TYPE OF TESTING AND INSTRUCTIONS : Urine testing ?
COUNTRY : CANADA LAB : University Health Network and Mount Sinai HospitalUniversity Health Network and Mount Sinai Hospital LOCATION : University Health Network and Mount Sinai Hospital, Fred A Litwin & Family Center for Clinical Genetics & Genomic Medicine, Toronto, Ontario M5T 3L9 TYPE OF TESTING AND INSTRUCTIONS : genetic testing CONTACT DETAILS : Phone:(416)586-4800 ext 4220; Fax: (416) 619-5523 COST and WAYS TO TEST : Must be referred by a physician to Dr. Chantal Morel for genetic testing. Covered under the National Health Plan.
COUNTRY : CANADA LAB : (Service suspended indefinitely) McGill University Health Centre, Montreal Children's Hospital, Biochemical Genetic Services LOCATION : Montreal TYPE OF TESTING AND INSTRUCTIONS : Urine (phenotype) testing CONTACT DETAILS : Email: annie.capua@mcgill.ca COST and WAYS TO TEST : Must be referred by a physician.
COUNTRY : CHILE Verónica Cornejo E., Jefa de LaboratorioLOCATION :Laboratorio de Genética y Enfermedades Metabólicas LOCATION : INTA, Av. El Líbano 5524 Casilla 138-11, Santiago CONTACT DETAILS :vcornejo@inta.uchile.cl
fono: 56-2-978-1491; Teléfonos Policlínico: 9781466 - 9781467 - 9781542; Teléfonos Laboratorio: 9781484 - 9781543; Fax: 2941254
COUNTRY : FRANCE LOCATION :Hôpital Georges-Pompidou à Paris, LOCATION : Paris. CONTACT DETAILS :service du Pr Germain, joignable au 01-56-09-28-01
COUNTRY : GERMANY LOCATION :University Children´s Hospital, Metabolic laboratory, Im Neuenheimer Feld 430, D-69120 Heidelberg LOCATION : Heidelberg TYPE OF TESTING AND INSTRUCTIONS : Urine testing; Test must be requested by a doctor CONTACT DETAILS : PD Dr Juergen G. Okun (PhD) Head of metabolic laboratory and newborn screening Division of Inherited Metabolic Diseases University Children´s Hospital Im Neuenheimer Feld 430 D-69120 Heidelberg Germany email: Juergen.Okun@med.uni-heidelberg.de COST :190 Euros. (Rate subject to change, check with provider)
COUNTRY : GERMANY LOCATION : Center for Human Genetics Regensburg, University Hospital, Building D3, Franz-Josef-Strauß-Allee 11, D - 93053 Regensburg, Germany TYPE OF TESTING AND INSTRUCTIONS : DNA (genotype) testing; and Carrier testing. METHOD : Analysis of the entire coding region : sequence analysis; Pre-test email/phone consultation regarding genetic test utilization and decision making is provided to patients/families. Post-test email/phone consultation regarding genetic test results and interpretation is provided to patients/families. CONTACT : phone: (+49) 941 9445410 fax: (+49) 941 944 5402 Director: Ute Hehr, MD email: info@humangenetik-regensburg.de
COUNTRY : IRELAND LOCATION : National Centre for Inherited Metabolic Disorders, Children's University Hospital, Temple St., Dublin 1; CONTACT : Prof Eileen Treacy, Metabolic Consultant, http://www.ncimd.ie/contact.html TYPE OF TESTING AND INSTRUCTIONS : Urine (phenotype) and DNA (genotype) testing; Must be referred by a Dr in writing to the address given; Specimen forwarded to Sheffield Children's Hospital, Dept. Clinical Chemistry, Sheffield, UK, Contact: Nigel Manning, Principal Clinical Scientist (see above) for same urine (phenotype) test
COUNTRY : JAPAN LAB : Showa Pharmaceutical University, Laboratory of Drug Metabolism and Pharmacokinetics LOCATION :Tokyo TYPE OF TESTING AND INSTRUCTIONS : Urine and DNA CONTACT DETAILS :website, Showa Pharmaceutical University, CONTACT : doutai@ac.shoyaku.ac.jp Hiroshi Yamazaki, PhD, Professor Makiko Shimizu, PhD, Research Associate Norie Murayama, PhD, Research Associate
COUNTRY : NEW ZEALAND LAB : Canterbury Health Laboratories LOCATION :Canterbury Health Laboratories,Corner Hagley Ave and Tuam Street, P O Box 151, Christchurch, 8140, New Zealand [b]CONTACT DETAILS : [/b]For general test enquiries LabInfo@cdhb.govt.nz Phone: (+64 3) 364 0300 Fax: (+64 3) 364 0750 Within NZ phone: 0800 THE LAB (0800 843 522) TYPE OF TESTING AND INSTRUCTIONS :Urine testing Tests : TMA & TMA-oxide ratio Test Identifyer and Instructions Ref range: normal is <25 umol/mmol creatinine Test includes dimethylglycine Technique used : NMR Dr referral not required. You can test direct COST : $300NZ (Rate subject to change, check with provider)
COUNTRY : SPAIN / ESPAÑA, Barcelona LAB : Hospital Sant Joan de Déu, Barcelona, Unidad de Enfermedades Metabólicas; LOCATION : Passeig de Sant Joan de Déu, 2, 08950 Esplugues de Llobregat, Barcelona; TYPE OF TEST AND INSTRUCTIONS : DNA (prueba de genotipado) CONTACT DETAILS : Teléfono: 34 932 53 21 00; Fax: 34 914974863; Sitio web Dra Mercedes Serrano Gimare, MD.
COUNTRY : SPAIN, Madrid Cantoblanco LAB : Centro de Diagnóstico de Enfermedades Moleculares, Universidad Autónoma de Madrid. Facultad de Ciencias; LOCATION : Calle Francisco Tomás y Valiente, 7, 28049 CANTOBLANCO, ESPAÑA; TYPE OF TEST AND INSTRUCTIONS : DNA (prueba de genotipado) CONTACT DETAILS : Teléfono: 34 914974589; Otro teléfono: 34 914974868; Fax: 34 914974863; Pr Magdalena Ugarte Pérez, email: mugarte@cbm.uam.es
COUNTRY : SPAIN, Madrid > LAB : Unidad de Enfermedades Metabólicas.
Servicio de Pediatría. Hospital Ramón y Cajal; LOCATION : Cra Colmenar Km 9,1. 28034 Madrid. ESPAÑA; TYPE OF TEST AND INSTRUCTIONS : ADN (prueba de genotipado) CONTACT DETAILS : Teléfono: 34 913368096 Fax: 34 913368417; Mercedes Martinez-Pardo Casanova. PhD. MD, email: mmartinezc.hrc@salud.madrid.org,
Amaya Bélanger Quintana, PhD. MD.
Magdalena Ugarde, M.D.
COUNTRY : SPAIN, Comunidad Valencia, PATERNA LAB : Instituto de Medicina Genómica
IMEGEN - Instituto de Medicina Genómica; LOCATION : Calle Catedrático Agustín Escardino, 9, E46980 PATERNA, ESPAÑA; TYPE OF TEST AND INSTRUCTIONS : Diagnóstico molecular de trimetilaminuria (gen FMO3 - secuenciación completa); CONTACT DETAILS : Teléfono: 34 963212340; Otro teléfono: 34 607524365; Fax: 34 963212341; info@imegen.es Dr. Javier García Planells, Director del laboratorio; email: Javier.garcia@imegenes >
COUNTRY : SPAIN, Comunidad Valencia; LAB : Fundación Investigación Clínico de Valencia-INCLIVA, Unidad de Genotipado y Diagnóstico Genético; LOCATION : AVDA Blasco Ibañez 17, Valencia 46010; TYPE OF TEST AND INSTRUCTIONS : ADNCONTACT DETAILS : Teléfono: telefono: 963862664; Fax: 963862665; email: a.barbara.garcia@uv.esa.barbara.garcia@uv.es
COUNTRY : UNITED KINGDOM LAB : Sheffield Children's Hospital, Department of Clinical Chemistry LOCATION : Sheffield, England; Persons outside the UK can test TYPE OF TESTING AND INSTRUCTIONS : Urine (phenotype) testing; Checks for TMA & TMAO; Reference range (normal) " TMA <10.9; TMA/TMAO ratio <0.21 CONTACT DETAILS : Nigel Manning,, Principal Clinical Scientist, Dept. Clinical Chemistry, Sheffield Children's Hospital; email: Nigel.Manning@sch.nhs.uk COST : Free on NHS, Must be referred through GP COST AND WAYS TO TEST : Best option is to give your physician the letter and TMAU information linked below from Nigel Manning, Principal Scientist, Sheffield Hospital. Nigel welcomes emails or phone calls from physicians:
COUNTRY : UNITED KINGDOM LAB : Sheffield Diagnostic Genetics Service LOCATION : Sheffield Children's NHS Foundation Trust, Sheffield Diagnostic Genetics Serice, Sheffield, UK TYPES OF TESTING AND INSTRUCTIONS : Analysis of the entire coding region: sequence analysis; Analyte and Carrier testing; can only accept contact from health care providers CONTACT DETAILS : Ann Dalton, PhD, FRCPath email: ann.dalton@sch.nhs.ukphone (+44) 1142 717003fax: (+44) 1142 750629
COUNTRY : USA LAB : The Human BioMolecular Research Institute (HBRI) LOCATION : Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, California 92121, (858) 458-9305, (858) 458-9311 fax TYPE OF TESTING AND INSTRUCTIONS :
Overnight-mail specimen or drop-off if live within geographical area. CONTACT DETAILS : *HBRI, San Diego, California, 5310 Eastgate Mall, San Diego, CA 92121; Telephone: 585 458-9305 Email : TMAUInfo@hbri.org
COUNTRY : USA LAB : University of Colorado, Denver
TMAu Testing Inquiries:
All TMAu testing is required to be ordered by an authorized physician. Please review the collection and handling instructions for TMA samples before sending in samples. Children’s Hospital Colorado
Biochemical Genetics Laboratory
TMAu with creatinine – Urine test only.
Price is $265 for clients.
Referral testing by provider ONLY.
Children’s Hospital Colorado
Precision Diagnostics
FMO3 Sanger Sequencing – DNA test
Price is $600
Referral testing by provider ONLY. Please perform the urine test first.
Lab Client Services – 720-777-6711 or LabClientServices@
Website: www.childrenscolorado.org/LAB DOES NOT BILL PATIENTS OR THEIR INSURANCE COMPANIES.
COUNTRY : USA LAB : Dr. George Preti, Monell Chemical Senses Center LOCATION : Philadelphia, PA; Dr. George Preti forwards specimen to the University of Colorado Denver and Health Sciences Center, Biochemical Genetics Laboratory, Department of Pediatrics TYPE OF TEST AND INSTRUCTIONS : Urine (phenotype)test only (phenotype test), Checks for: TMA level and TMA-O level Reference range: TMAO/TMA ratio >85% TRANSPORT METHOD AND TEMPERATURE: Contact Dr. George Preti and he will send you a kit with instructions CONTACT DETAILS : Please contact Dr. George Preti directly, preferably by email, and he will send you a kit for $75. Someone will advise with regard to the procedure to follow to get the testing done: email -- Preti@monell.org phone: 1-267-519-4920 http://www.monell.org/contact_us/tmau/ COST : WAYS TO TEST : No doctor's orders required, medical insurance policies will not cover without doctor's orders
COUNTRY : USA LAB : University of Colorado Denver and Health Sciences Center, Biochemical Genetics Laboratory, Department of Pediatrics LOCATION : Denver, Colorado; TYPE OF TEST AND INSTRUCTIONS : DNA Test; CONTACT DETAILS: See website :http://www.uchsc.edu/dnalab/ Email: amber.brand@childrenscolorado.org phone : (720) 777-2723 COST :is usually approximately $600; WAYS TO TEST :Doctor or a TMAU expert's referral required; Officially you must do the urine test first.
COUNTRY : USA LAB : The Mayo Clinic LOCATION : The Mayo Clinic Medical Laboratories, Superior Drive Support Center, 3050 Superior Drive NW, Rochester, MN 55901; The Mayo Clinic forwards sample to another lab TYPE OF TEST AND INSTRUCTIONS : Mnemonic Test WILD105, Mayo Unit Code 90544, Test Name – TRIMETHYLAMINE (FISH ODOR), URINE, CPT Codes – 82491, 80500; Methodology – GC Gas Chromatography **Samples must be shipped Monday – Wednesday only. TRANSPORT METHOD AND TEMPERATURE: Please utilize our Mayo Medical Laboratories website at http://www.mayomedicallaboratories.com/. This site will guide you in getting a specimen to use for testing. If you have further questions please call 800 533 1710”. CONTACT DETAILS : Mayo Medical Laboratories website at http://www.mayomedicallaboratories.com/. This site will guide you in getting a specimen to use for testing. Customer Service staffed with 24-hour personalized service: http://www.mayomedicallaboratories.com/customer-service/index.html United States, Canada · 800.533.1710 · 507.266.5700 · mml@mayo.edu International · 507.266.5700 · mmlglobal@mayo.edu COST : $144.20 (Rate subject to change, check with provider) WAYS TO TEST : With doctor’s orders only; most medical insurance policies will cover
COUNTRY : USA LAB : PreventionGenetics, Molecular Diagnostics and BioBanking, Marshfield, WI LOCATION : 3700 Downwind Drive, Marshfield, Wisconsin 54449 USA TYPE OF TEST AND INSTRUCTIONS : FMO3 DNA test (full sequencing); Deletion/duplication analysis CONTACT DETAILS : Thomas L Winder, PhD, FACMG phone: (715) 387-0484 ext 118fax: (715) 384-3661 email: tom.winder@preventiongenetics.com COST : $670 (Rate subject to change, check with provider)(please confirm when you book) WAYS TO TEST :Test Requisition Form (print and give to your physician) TMAU listed in list on preventiongenetics.com site
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UK 
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