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MEBO - UBIOME study 2018

NCT03582826
ClinicalTrials.gov
MEBO Gut Microbiome Study
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

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Metabolomic Profiling Study
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Monday, April 23, 2018

Conference Presentation by Danny Kunz



As usual, Danny Kunz most graciously provided the MEBO community with a very informative PowerPoint presentation on the Causes of Body Odor. This PowerPoint was to be presented and discussed at length at the MEBO Annual Conference, Savannah, Georgia 2018. Since we did have some technical difficulties and we were unable to hear the video, I am now presenting it here.

Discussion below on some points of interest that Danny tells us:

Histamine in the gut is bad because it has a strong impact on tight junction regulation of intestinal cells. In fact, "fecal body odor seems to be related to histamine degradation deficiency" The significance of gut wall health (tight junction regulation of intestinal cells) was discussed in the conference. Sufferers are recommended to consult with their physician if they experience prolonged allergic reactions, especially of the bowels, such as food sensitivities and/or indigestion, etc.

It is important to maintain good health of the digestive tract in the fight against odor conditions and PATM. Sufferers are recommended to consult with their gastroenterologist when experiencing any intestinal discomfort, including but not limited to, bloating, constipation, diarrhea, abdominal tenderness, painful bowel movement, hemorrhoids, rectal bleeding, etc.


It looks like histamine concentrations are highly important for the tight junction regulation of intestinal cells.

The tight junctions are important for the direct paracellular transport of electrolytes into the blood without transition through the intestinal cell metabolism.

Increased open tight junctions [leaky gut] will further lead to an increased surface area of the intestinal cells [IBS] and are as a result, a strong regulator of passing amines and their level of being processed.
http://bodyodorresearch.blogspot.com/2017/05/histamine-has-strong-impact-on-tight.html


Clinical significance of the opening of intercellular tight junctions (increased intestinal permeability), any of which may result in opening of tight junction, resulting in the passing of electrolytes into the blood without transition through the intestinal cell metabolism.

Clinical significance [Wikipedia]


The opening of intercellular tight junctions (increased intestinal permeability) allows uncontrolled passage of substances into the bloodstream, with subsequent possible development of immune and/or inflammatory reactions.[3][8]
The opening of intercellular tight junctions (increased intestinal permeability) can allow passage of microbes, microbial products, and foreign antigens into the mucosa and the body proper. This can result in activation of the immune system and secretion of inflammatory mediators.[12]
Increased intestinal permeability is a factor in several diseases, such as Crohn's diseaseceliac disease,[13] type 1 diabetes,[14]type 2 diabetes,[13] rheumatoid arthritisspondyloarthropathies,[15] inflammatory bowel disease,[8][16] irritable bowel syndrome,[9]schizophrenia,[17][18] certain types of cancer,[8] obesity,[19] fatty liver,[20] atopy and allergic diseases,[14] among others. In the majority of cases, increased permeability develops prior to disease,[8] but the cause–effect relationship between increased intestinal permeability in most of these diseases is not clear.[16][21]

For a clearer understanding of the above used terms, see illustration below:
  1. Transcellular route (pathway): The route through cells, as opposed to between the cells.
  2. Paracellular route: the route between cells
  3. Tight junction: A type of cell junction formed between epithelial cells of vertebrates wherein the outer layers of two adjacent cells fuse, thereby serving as a barrier to the passage of fluid between cells
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María

María de la Torre
Founder and Executive Director

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