Our 600th post : Blog index

This our 600th post in this blog, which was inaugurated on May 26, 2008, will attempt to give a brief index of the various body odor topics addressed this past year and a half. We hope this facilitates access to the desired subject matter.

Systemic Body Odor Conditions :

metabolic enzymes

• 2001 FMO Paper : Study on Human FMO1 and FMO3 development. FMO1 the main hepatic form before birth. FMO3 after birth.
• Paper: Transient trimethylaminuria in childhood, not because of poor enzyme function : 1998 Paper
• Neonatal with a cabbage smell: and the background of how many 'lesser' health problems are 'discovered'
• The phase 1/phase 2 biotransformation enzymes

FMOs

• 2008 Dr Cashman paper: Role of flavin-containing monooxygenase in drug development
• 2006 paper : FMO3 'in action'
• FMO3 paper hints at 25% possibly with FMO3 issues in a trial
• CYP450 enzymes explanation, from a 'drug metabolism' viewpoint

xenobiotics

• Xenobiotic metabolism enzymes : an attempt at an explanation
• Drug metabolizing enzymes : FMO3 is one such enzyme
• Environmental Impacts on Enzymes involved in metabolism
• Environmental Impacts on Enzymes involved in metabolism

Trimethylaminuria (TMAU)

• TMAU papers
• TMAU references
• Mystery diagnosis episode about Trimethylaminuria featuring Cheryl Marshall and Dr Paul Fennessey

Halitosis: alveolar breath odor

Possible Systemic or Localized Body Odor Conditions :

hyperhidrosis, bromhidrosis, foot odor, oral sourced halitosis

• 2009 paper on underarm body odor : Acid odor precursors in axillary secretions

Vaginal odor

• Non-infectious and infectious causes of vaginal odor
• Trimethylaminuria: A Noninfectious Cause of Vaginal Odor
• Dr Jelovsek explains Vulvar and Perineal Odor

Gut Dysbiosis :

• Could leaky gut be a factor in Fecal Body Odor ?

• Leaky gut - Liz Lipski booklet

• Bacterial Dysbiosis

• Part 1 and Part 2 of interview with Cass Nelson-Dooley of Metametrix includes discussion on short chain fatty acids (SCFAs) and bacteria

• Video: presentation of Metametrix GIfx stool test by Richard S Lord

Testing :

• TMAU Testing International

• Detoxigenomics dna test by Genova Diagnostic: tests many detox enzymes but not FMO3

Breath Analysis posts

• Gas Chromotography

• Mass Spectrometry

Volatile Organic Compounds (VOCs)

• Sulfur and hydrogen sulfide (smells of rotten egg)

• Methanogens versus the sulfate-reducers in the colon

• 1999 Research paper on hydrogen sulfide and methanethiol in the cecal mucosa (Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa.)

• Hypothesis : what would a thorough examination of a fecal body odor sufferers system look like ?

• Research into a breath test for testing for Volatile Organic Compounds associated with serious illnesses.

Microorganisms in body odor :

• TMA and hydrogen sulfide odor-producing bacteria in the gut and or vagina

• D-lactate acidosis in chronic fatigue syndrome

• Shewanella baltica and other TMA producing bacteria in the gut

• Metametrix Methodology: Polymerase Chain Reaction (PCR)/ DNA microbial testing

• Interview with Cass Nelson-Dooley of Metametrix : Part 1 (TMA-producing bacteria)

• aerobic and anaerobic bacteria, including gardnerella, corynebacteria, shawanella

• yeast and molds, including candida/candidiasis or bacterial

• Vaginosis

Gut Dysbiosis :

• About the leaky gut test (intestinal permeability test)

• Leaky gut (intestinal permeability) urine test can be bought online for around $90

• Leaky gut - Liz Lipski booklet

• Could leaky gut be a factor in Fecal Body Odor ?

• Leaky Gut Syndrome

• “Leaky gut is often involved in cases of dysbiosis…” Cass Nelson-Dooley, Clinician, Metametrix

• Video: presentation of Metametrix GIfx stool test by Richard S Lord, Director, Department of Science and Education, Metametrix Clinical Laboratory

• Dysbiosis : Scientists find a bacteria that may be important in Crohn's disease

• Metametrix slideshow of case study of patient with dysbiosis and leaky gut

Gut fermentation : Clinical gut candidiasis tests

Metabolic enzymes

DNA/Genetics

• Genes for dummies: a simple video guide (4 parts)

• 2008 dissertation paper on TMAU DNA : 8 out of 12 had no (known) mutations

Odor Management :

• An odor-reducing management protocol discussed in the Thames Festival meet-up Parts 1 & 2

• Treatment of Manifestations of the Gene Reviews article on Trimethylaminuria

• Three main protocols of TMAU diet

• The 4 “R” Protocol for Intestinal Health from the GI Effects Interpretive Guide: Remove, Replace, Reinoculate, Repair.

Enzyme replacement theory :

• Hypothesis: genetically modified probiotic for trimethylaminuria

• Genetically engineered bacteria : one possible treatment for TMAU

Prebiotics and probiotics :

Prebiotics

• A retired gastroenterologist's view on prebiotics and the gut microflora

• Cass’s views on prebiotics

Probiotics

• The different types of probiotics

• Probiotics: Metabolic interactions in the gut

• Probiotics: local civilians and special forces ?

• The Barron Report: The Probiotic Miracle

• Video : introduction to probiotics

Flagyl and Nystatin for fecal body odor ?

Antibiotics

Could PTC124 help with primary trimethylaminuria due to a nonsense mutation ?

TMA and hydrogen sulfide odor-producing bacteria in the gut and or vagina

Interview with experts

Research Efforts

• MEBO Research,non-profit organization, projects

• Australian Trimethylaminuria Foundation (ATF), Trimethylaminuria research proposal by Dr John Christodoulou

• NORD TMAU Fund