The 1st Women's conference call : thanks to our guest Kathy and all that attended.

Thank you to all the ladies who joined the 1st Women's Conference Call last night, especially Kathy (aka author Carry Wilson) who told us of her battle against metabolic body odor and is bravely raising public awareness on the issue on all our behalfs. Hopefully it was a much needed release for all the ladies who attended, and hopefully will become part of our support strategy to help us through these difficult times and shape our thoughts into coming up with solutions and strategies as sisters.

Dont forget the normal conference call this Sunday for everyone (to be confirmed), August 3rd at 2pm EST.

Also remember the conference call line can be used anytime for chats or group meetings. Anything to do with support or progress.
For USA-based : (712) 432 1620 then type the access code on your phone keypad: 391629#
Non USA : prefix above with 001 but check to see if it is free with your supplier
If privacy is a concern, code your phone to PRIVATE mode.
If your phone doesn't have private mode, use the prefix hiding code for your country

Kathy's book, under the author name Carry Wilson, is available from here in paperback or as a downloadable ebook. Thank you Kathy.
http://www.dorrancebookstore.com/foboodthalki.html

Manual lymph drainage

It has to be assumed manual lymph drainage will have minimal effect on bloodborne body odor or bloodborne halitosis, but the lymph is part of our drainage system. The therapy seems to involve draining the lymphs. It is almost certainly not a solution, but may help with detox. It is mentioned only for awareness purposes. It is not an endorsement. Skin brushing is to push the lymph to the nodes. Manual Lymph Drainage must be a stronger form of this motion.



Random links:
manual lymph drainage : healthandgoodness.com article
lymph system video: explanation on youtube
video of main lymph node locations: expertvillage.com video
lymph system explained: medline definition of lymph system
lymph system explained: lymphnotes.com article

Poll: Bloodborne Halitosis: Does alcohol ever make your kidneys hurt ?

Interview with author, Kathy Watson (author name: Carry Wilson)

During my interview with Kathy this evening, I fell in love with the strong spirit I found in her that fights to survive and to not surrender to the oppression that weighs upon her and brings her down repeatedly, only for her to bravely stand up again. “My depression is 100% caused my odor, and for years my doctors kept denying that I had it, and living in the ghetto, my friends were mean to me about my odor,” she said. “I thought I was going crazy. I had four major breakdowns and was hospitalized with depression. The hospital was a relief for me because it took me away from the outside world where I had to live with this odor.”

Kathy began to go to the library regularly to seek answers to her condition. The librarian taught her to use the computer, and 7 years later, she found information about TMAU. This was the turning point in her life. Although she is still on her road to recovery from the heavy burden of depression, as there still is no cure for TMAU, one only has to look back to where she began her struggle with her malady to see what a fighter she is and what inner strength and determined will power she has had throughout these years. Not only has she accomplished to use a computer well and to understand the medical terms, but also to write her own book in her effort to face her ordeal against all odds.

Kathy, we look forward to getting to know you personally and to share our thoughts and experiences with you as well, so that we can all grow together as a family who understands and cares for each other like no one else could. I couldn’t think of a better person to inaugurate our Women’s Free Conference Calls.

Women's Conference Call Inauguration Tomorrow : Wednesday 30th July

It is with great pleasure that I write this post today. Tomorrow on the 2nd month anniversary of this blog, and approximately three months after the inauguration of Cabel’s General Conference Calls, Tisha will inaugurate the bi-weekly Women’s Conference Calls, which will serve as a place of refuge where women with similar physical and emotional challenges can come together to share how each faces these challenges. Here we will explore our womanhood as single women, women in relationships, in motherhood, and women in the workforce. Kathy Watson (a.k.a. Carry Wilson, author of her autobiography, The Foul Body Odor that Almost Killed Me), will be our inaugurating honored guest. All women are welcome to join us!

Women's Free Phone Conference: Wednesday 8pm EST

Next call: July 30th at 8:00 pm EST
GUEST SPEAKER : Carry Wilson

For USA-based: (712) 432 1620 then type the access code on your phone keypad: 391629#
Non USA : prefix above with 001 but check to see if it is free with your supplier

Record number of callers : 70+
If privacy is a concern, code your phone to PRIVATE mode
This phoneline can be used anytime to talk to other sufferers

Click below to read my taster interview with Kathy/Carry

During my interview with Kathy this evening, I fell in love with the strong spirit I found in her that fights to survive and to not surrender to the oppression that weighs upon her and brings her down repeatedly, only for her to bravely stand up again. “My depression is 100% caused my odor, and for years my doctors kept denying that I had it, and living in the ghetto, my friends were mean to me about my odor,” she said. “I thought I was going crazy. I had four major breakdowns and was hospitalized with depression. The hospital was a relief for me because it took me away from the outside world where I had to live with this odor.”

Even though Kathy was a high school drop out, and couldn’t read well, she began to go to the library regularly to seek answers to her condition. The librarian taught her to use the computer, and 7 years later, she found information about TMAU. This was the turning point in her life. Although Kathy is still on her road to recovery from the heavy burden of depression, as there still is no cure for TMAU, one only has to look back to where she began her struggle with her malady to see what a fighter she is and what inner strength and determined will power she has had throughout these years. Not only has she accomplished learning to read, to use a computer well, but also to write her own book in her effort to face her ordeal against all odds.

Kathy, we look forward to getting to know you personally and to share our thoughts and experiences with you as well, so that we can all grow together as a family who understands and cares for each other like no one else could. I couldn’t think of a better person to inaugurate our Women’s Free Conference Calls.

Non-infectious and infectious causes of vaginal odor

It is important to stress that bacterial vaginosis (BV), is not the only source of vaginal odor produced in women who may suffer from a metabolic condition. Vaginal odor may be present as a result of non-infectious TMA and other odorous toxins in the vagina. It is, however, important to stress the need for regular checkups, especially when presenting with BV symptoms, to help minimize vaginal odor.

Since many women assume they have a yeast infection and treat symptoms with over-the-counter medications, sometimes BV, including Gardnerella vaginalis, Gardneralla mobiluncus, and Mycoplasma hominis, go untreated and may also be a source of odor. This could lead to complications such as pelvic inflammatory disease (PID), female infertility, tubal (ectopic) pregnancy, and childbirth and infant complications. Some of the signs and symptoms of BV are,

A fishy vaginal odor, itching, and irritation are common signs of BV and may be particularly noticeable after intercourse or menses. It may be accompanied by a smooth, sticky white or gray discharge 4 days to 4 weeks following exposure. Elevated vaginal pH level is also a symptom.

Odor-reducing techniques for metabolic causes of vaginal odor will be discussed in our July 30th Women's Conference Call.

http://www.urologychannel.com/std/gardnerella.shtml

Homeworking idea : Homebaking, an interview with a baker.

There are many benefits in working from home such as setting your own hours, being able to raise your children, taking them to school, to sporting events and other extracurricular activities, taking care of elderly or sick family members, to name a few, and still enjoy the sense of accomplishment by being a provider for yourself and your loved ones.

Although not all personalities prefer to work at home and some may instead find a more social type setting more enjoyable, to a body odor sufferer, the more recluse home environment represents an escape from the constant ridicule and rejection from co-workers sufferers face in more social settings.

This is a very interesting interview with one of our own Body Odor Support forum member, Sonya (a.k.a. lucyloo2000), who operates her home cake decorating business. She shares with us the reason for her decision to work from home, the pros and cons, and tips on how to run a home business like hers.

Sonya, thank you so very much for sharing this information with us. I’m certain there are many sufferers out there looking for alternatives to their very difficult work environment, and you seem to have found one that works for you. Sharing your experiences with us can guide us in this very important decision-making process.

Click below to read my interview with Sonya


MARIA: What gave you the idea of starting a home cake decorating business?

SONYA: Well, ever since I was a small girl, I always have loved to cook and make things for other people. I was always drawing and doodling in notebooks. I carried the love of cooking and drawing with me into adulthood. I never knew that I could put the two together and come up with cake decorating. The first cake that I made was for my youngest son's 2nd birthday. I bought a Wilton book and followed the recipe and directions step by step. To my delight, the cake was beautiful, and everyone who saw it could not believe that I made it. My family members were my first customers. It was a great feeling, to know that I had a talent for something. I was already painfully aware of my odor condition during this time. I had lost several friends because of the condition, and I was very depressed. Getting into the cake business helped my self esteem and sense of self worth. It gave me an outlet to express myself.

MARIA: What would you say are the pros and cons of starting a home business venture like this?

SONYA: The pros of this business
+ You can set your own hours and work as much and or as little as necessary
+ The only interaction with customers is over the phone when the order is placed and when the cake is picked up. Very little on the spot interaction
+ I can stay home with my kids in the summer and also be here to take them to and from school, and work during the day when they are at school.
+ I am a shy person and this allows me to work at home and have a sense of accomplishment without having to go through the social issues in the workplace.
+ I order all of my supplies online, except the cake ingredients.
+ It is a creative outlet.
+ People buy these cakes for special events, and you have the opportunity to make their day a little nicer. You can add your special touch to their special day.
+Very little time is actually spent with the customer, and they are usually so excited about the cake, that they don't even seemed bothered with the BO issue.

The cons: - You have to take orders when they come.....if you have plans or events scheduled, you have to be available for the customer. When you turn down a customer, you may loose potential business from them or their friends in the future. My advice is always put the customer first. You must be available and flexible.
- Cake baking and decorating takes patience. It is a step by step process that cannot be rushed. You must be able to stand on your feet in one spot for several hours. it's time consuming.
_ the initial start up can be costly. I have over 100 pans, but it took a while to get all of them. I bought most of them on e-bay or at yard sales. This saved me quite a bit.
- for me the pros outweigh the cons.

MARIA: How do you develop a clientele, by referrals, advertising to wedding planners or to any organizations, etc?

SONYA: I developed a clientele by word of mouth. I took several cakes to school functions, and it snowballed from there. I made sure that I had business cards printed and placed on top of the cake boxes. Also I give several cards to customers when they pick up their cake. They give them to friends and relatives and more business follows. The best advertising I have found is by word of mouth. Make your cakes fresh and think of your customer first, Ask yourself what would I want this cake to look like, taste like.....if I were the customer.
Good communication is a must. The customer must get exactly what they ask for, because they are paying you for your services.
Another thing is to make sure your cakes are priced fairly. Don't overcharge. Look around at your local bakery and price your cakes slightly below theirs.

MARIA: Is there anything else you want to say to sufferers who might be interested in starting a home-baking business or a home-food catering business?

SONYA: If you are interested in developing your own home cake decorating business, go for it. Take classes if you don't know how to decorate. Use the internet as an instructional tool. I do this all of the time. You can find anything on the net. Don't give up on life. Find something you enjoy and go for it! I also love to take pictures, and I may get into that sometime. Do something as a hobby or part time before you go head over heels into it though. You have to feel out the waters and see if you get any bites.
Many of us have undiscovered talents. We can use our talents in home based business and in the process have a great time, and help support our families.

random homebaking links:
ideas : http://www.wilton.com/cake/index.cfm
ehow article : http://www.ehow.com/how_2056888_start-home-baking-business.html
motherearthnews article : http://www.motherearthnews.com/Modern-Homesteading/1983-01-01/At-Home-in-the-Baking-Business.aspx

pep-talk : the haka

Ka Mate! Ka Mate!
Ka Ora! Ka Ora!
Tenei te ta ngata puhuru huru
Nana nei i tiki mai
Whakawhiti te ra
A upane ka upane!
A upane kaupane whiti te ra!
Hi!!

English Translation:
It is death! It is death!
It is life! It is life!
This is the hairy person
Who caused the sun to shine
Keep abreast! Keep abreast
The rank! Hold fast!
Into the sun that shines!

Handbook of Drug Metabolism - Google Book Search

This is a respected book on the drug metabolizing enzymes (1999). The chapter on Flavin Mono Oxygenase enzymes is written by the well known respected FMO expert, Dr John Cashman of HBRI. Given that little research goes on with regards FMO, but more research has been done recently, it is unclear how up to date the chapter will be.

Of interest is where Dr Cashman says lowered FMO function is likely to be associated with other metabolic conditions since this doesn't seem to be the general impression given from medical websites/books. Google books has pages missing, but you can get a general sense of the enzyme from the chapter.

Handbook of Drug Metabolism (1999)
Edited by Thomas F. Woolf

Finally, the role of FMO in human disease conditions is certain to be studied in increasing detail in the future. The abrogation of human FMO3 has been associated with trimethylaminuria, but it is likely the variant forms of FMO are associated with other abnormal metabolic conditions because trimethylaminuria patients appear to suffer from a number of other disease states as well. With the emergence of new and sensitive selective molecular probe of human FMO, it is possible that a role of FMO in human disease conditions will be clarified...

http://books.google.com - the chapter on FMO enzymes from the Handbook of Drug Metabolism

Lifestyle : Salutation to the sun

other: http://www.youtube.com/watch?v=oBc5vquG33U
youtube search: yoga

Asparagusuria

Very little scientific research seems to have been devoted to why and what makes asparagus consumption result in the person having smelly urine in some cases, and not in other people's cases. Of the little research regarding asparagusuria found in Pubmed, the points made are contradictory, but for now it may be prudent to go with the conclusions based mostly on research by Mitchell and Waring, since they have done the most, but also take the few other papers into consideration. The observations were :

1. The smelly urine is a genetic autosomal dominant rule. Meaning they suggest you only need one 'copy' of the responsible gene for the condition to occur. This is the opposite of what the medical books generally regard TMAU (autosomal recessive. Meaning you need 2 bad copies). If it turned out 'bloodborne odors' was autosomal dominant, it would bring in a lot more people into the equation of having bloodborne body odor. It does seem that one or more TMAU experts probably do now feel that 'transient' TMAU is likely to be autosomal dominant, given some of the papers on pubmed, although it doesn't seem to be a current official 'rule'.

2. About 40% (in one study) were regarded as being unable to smell the urine whether it was theirs or anyone elses (non-perceivers)

3. there are 3 possible outcomes:
no smell from the urine (the smelly metabolites are not there - non-excretors)
the urine smells (excretors)(in about 8% of the UK Caucasian population it is super-smelly, since they have 2 copies of the excretor gene - homozygous)
the urine smells but the sufferer can't smell it (excretors but non-perceivers).
However, none of the above outcomes is 'official', since the few papers give contradictory outcomes.

There is the possibility that the asparagusuria urine test could be a cheap test for potential bloodborne body odor cases, but this must currently be considered unlikely. Possibly the bloodborne BO cases would be the super-smelly urine cases, with them also being unable to smell their own urine, same as what seems to happen in most bloodborne BO cases. An expert suggested that one possibility is that those who excrete super-smelly urine may be 'non-perceivers' because their smell receptors could be already saturated.

Overall, nothing can be deduced from this post in connection to bloodborne body odor/halitosis, and it is posted only as something to think about.

pubmed asparagus odor urine search
Mitchells last paper (2001) on Asparagusuria
Interesting comments on Wisegeek.com

Try the asparagus urine test.
Poll : Did your urine smell ? click below

note : the inabilty to smell asparagus urine is not taken into account in the polls

Nasopure nasal irrigator

After the recent Netipot post, a poster replied that they find the Nasopure cleaner better and easier to use. Dr. Hana Solomon, Pediatrician, invented this nasal wash of the nasal floor for nose and ears problems, and even asthma. She gives a great explanation of its benefits, including reducing bad breath and increase your sense of smell.

Nasal irrigator poll below : Which nasal irrigator do you prefer ?

Carry Wilson autobiography : The foul body odor that almost killed me

This autobiography was self-published in 2007 by one of our very own TMAU sufferers, Carry Wilson. This testimonial is a very deep and candid account of her experiences with the social and emotional obstacles sufferers face on a daily basis. It clearly portrays the personal profound devastation these obstacles produce, and its impact on the sufferer’s family. Each page screams out the desperate need for research and a cure. Thank you Carry for bravely telling your story, helping to break down the stigma attached to this malady, and for representing us all in our plight!

Carry will be speaking on the inaugural Body Odor Support Forum Women’s Conference Call next Wednesday, July 30th at 8:00p.m. EST.

Plagued by a terrible odor that not only proved to be embarrassing but also made it difficult for her to hold a job and to provide for herself and her young daughter, Carry Wilson sought help from a number of physicians in various fields. Despite the indications of her own research, medical professionals repeatedly dismissed her concerns and assumed she suffered from a psychiatric disorder rather than a medical illness. Desperate, isolated, and depressed, she was hospitalized several times with suicidal ideations, a history that only seemed to make it more difficult to secure quality medical attention.

Use CheapestBookPrice.com for a quick search using ISBN-10: B0010KDSTY
Paperback
Author: Carry Wilson
Publisher: Dorrance Publishing Co., Inc.
Release Date: 2006

The book or Ebook is available from the publisher :
http://www.dorrancebookstore.com/foboodthalki.html

ISBN: 978-0-8059-7188-0
ASIN: B0010KDSTY

It is also available from Amazon and possibly elsewhere:
http://www.amazon.com/Foul-Body-Odor-Almost-Killed/dp/B0010KDSTY

Your MD can do the TMAU urine test via the Mayo Clinic test service

The Mayo Clinic accepts urine samples for TMAU testing only with your Physician's written orders for the Mnemonic Test WILD105, for the cost of $144.20. As per the Customer Service Lead at the Mayo Clinic instructions, please see their website for additional information, “Please utilize our Mayo Medical Laboratories website at http://www.mayomedicallaboratories.com/. This site will guide you in getting a specimen to use for testing. If you have further questions please call 800 533 1710”.

The Mayo Clinic also faxed us the form below for us to print and give to our physician so that he/she prescribe the testing procedure; this form includes instructions on how to handle and ship the specimen. We may then mail the physician’s order and the urine sample to:

The Mayo Clinic Medical Laboratories,
Superior Drive Support Center
3050 Superior Drive NW
Rochester, MN 55901

The Mayo Clinic test page : http://www.mayomedicallaboratories.com/test-catalog/Overview/90544

Customer Service staffed with 24-hour personalized service:
http://www.mayomedicallaboratories.com/customer-service/index.html

United States, Canada
· 800.533.1710
· 507.266.5700
· mml@mayo.edu
International
· 507.266.5700
· mmlglobal@mayo.edu

Copy and paste form below with full instructions for your physician and lab

Mnemonic -
WILD105

Mayo Unit Code -
90544

Fee -
$ 144.2

Test Name -
TRIMETHYLAMINE (FISH ODOR), URINE

CPT Codes -
82491, 80500

Methodology -
GC Gas Chromatography

Test Notes -
Samples must be shipped Monday - Wednesday.

Referral Lab -


Transport Method and Temperature -
15-20 ml RANDOM FROZEN- URINE and/or aliquot of post-load speciment.
Adjust urine to pH -5.0 using a small volume of concentrated HCl.
Fill several GLASS tubes (glass screw-cap tubes or glass red-top vacutainer tubes)
HALF FULL to allow for expansion of the specimen due to freezing.
FREEZE, CUSHION WELL TO AVOID BREAKAGE.
TRIMETHYLAMINE IS A HIGHLY VOLATILE COMPOUND AND WILL BE LOST FROM THE SPECIMEN IF THESE INSTRUCTIONS ARE NOT FOLLOWED.
SPECIMENS SHIPPED IN PLASTIC OR NOT FROZEN WILL BE REJECTED.

---

---

Update: A full list of known TMAU test labs can be seen on our MeBO Map

Note: Your MD can alternatively send a sample direct to the Arkansas Lab for a trimethylaminuria urine test

Important : The Trimethylaminuria urine test is a challenge test. A dose of choline should be taken. It is currently unclear how the Mayo clinic advise the use of choline in the test.

ARUN NAGRATH'S SCIENTIFIC QUESTIONNAIRE

The scientific questionnaire Arun has been telling us about is now avaliable for sufferers to participate in. This questionnaire was originally devised and modified by Arun Nagrath in consultation with a consultant in metabolic medicine/TMAU and with the assistance of others in the internet body odor/halitosis community, with the intent of using the results to promote funding and research to find a better understanding of metabolic body odor and halitosis.

The greater the participation from sufferers, the more valid the results will be so please make sure you take time to fill it out as accurately as possible. It is the sincere hope of this endeavor to move experts to become inspired and dedicated to the exploration this very devastating problem that substantially limits one or more major life activities in a significant percentage of the human population around the world, including the ability to maintain employment and productive social function

We especially thank the gentleman from Arun's meet-up of the 14th and 15th of June, 2008, who worked so diligently in creating the questionnaire database, and to one of our CureZone members who coordinated the creation of this project, and for Arun who inspired and guided us through this process. Their contributions have been invaluable. Our most sincere gratitude goes out to them for their outstanding fine work in bringing this scientific tool to fruition.

You can access the questionnaire at: http://www.tmau.shareaflat.net/

Poll : Bloodborne halitosis : Are your scalp muscles tensed up ?

Alice Mata 1999 self-published TMAU book : When bathing is not enough

This is thought to be the first autobiography by a trimethylaminuria sufferer: Alice Mata. It looks like the book was published and written on her own initiative around 1999.

In her captivating literary style, Alice valiantly brings her readers to the depths of her shame-filled world of body odor. Being ahead of her time, she pioneers the road for all sufferers and non-sufferers alike to find words to express the heart-wrenching struggles and challenges of living with the alienating condition she faces day after day. Through her autobiography, Alice heightens awareness of the systematic emotional and social estrangement sufferers are forced to endure as a result of the profound ignorance that exists regarding this condition.

I awoke early to a beautiful summer day, and felt a great surge of love as I heard my children going about their morning routine. My oldest son, 18, getting ready for work, and my other son, 16, and daughter, 14, getting ready to go to Band practice at the Local High School. I should get up and fix them breakfast, I thought, but once again, a gloomy, heavy depression begins to engulf me, as many embarrassing incidents come to mind. Over and over, I ponder each one, analyzing and trying to find some other reason or explanation for each occurrence; hoping in vain that I misinterpreted the clerks in the stores, the waiters and waitresses in restaurants, the girls at work, some of my neighbors, relatives, some of my children's friends, and all the many other people I have encountered over the years, who have either by action, comment, or innuendo, led me to believe I smell bad. I remember the humiliation each time I pretend not to notice, the despair at not knowing what it is or what to do about it, and the indignation when they right away conclude that perhaps I don't bathe or use a deodorant; for you see, I am one of those few unfortunates who, despite fastidious grooming, and careful use of the best known brands of deodorants, still suffer for the very hush! hush! problem of body odor.

This book may still be available on sites like Amazon and Ebay, or you can buy it from the original publisher. There is also a downloadable Ebook version :

www.authorhouse.com/BookStore/ItemDetail.aspx?bookid=2195
the link should work if you paste the full address into the browser address bar

other sellers
Amazon USA : When Bathing is Not Enough

openlibrary.org entry for Alice Mata: When bathing is not enough

Pep-talk

Join me in 20JUL08 Conference Call: Parenting a BO Sufferer

Our bi-weekly Conference Call Coordinator, Cabel Hall, asked me if I wanted to discuss my experiences in parenting a BO sufferer in our next conference call to be held on July 20, 2008.

In light of the strong response to the recent posts in MSN regarding whether to have children as a result of a BO genetic condition, and my post of my experiences as a parent of a BO sufferer, I think this would be a very interesting topic of discussion for us to have. So, do join me this Sunday to explore this tremendous part of our lives. I’ll be looking forward to it.

In addition to telling my story of what has worked and hasn't worked for my son and me, I invite you to bring your own personal experiences as sons/daughters, as potential parents being sufferers yourselves with fears and anxieties regarding passing this malady to your children, and/or your personal experiences as parents of children with BO.

María (mpdela)

Positivity : Memory foam topper

Trimethylaminuria: A Noninfectious Cause of Vaginal Odor

This is a 2006 paper involving Mitchell/Smith from the UK. Trimethylamine is regarded as causing the fishy smell of Bacterial Vaginosis, and in this paper they check the vaginal TMA levels of 2 TMAU sufferers with that of some women diagnosed as having bacterial vaginosis.

Two patients who were previously diagnosed with inherited (primary) fish-odor syndrome (trimethylaminuria) were examined for the presence of trimethylamine in their vaginal secretions. Their samples were compared with those obtained from a healthy control group and a cohort of patients with bacterial vaginosis (BV). As expected, those with BV secreted larger amounts of trimethylamine than the control group. However, the two patients with trimethylaminuria—although presenting with no vaginal/cervical pathology—secreted trimethylamine levels that were at least double those found in the patients with BV. This suggests that trimethylaminuria may be an underlying but unappreciated cause of vaginal malodor (especially fish-like odor) in patients found to be infection-free...

http://www.femalepatient.com/html/features/031_03_010.asp

Poll : Bloodborne halitosis : Do you have any allergies ?

TMAU and acidic ph washes : are feminine washes an option ?

The general advice for TMAU is for sufferers, men and women, to use a wash/gel with an acidic ph, around 5.5, in the hope it will make the tma on the skin less volatile. Most ordinary soaps are probably slightly alkaline.

Quote from this source : http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=trimethylaminuria#trimethylaminuria.Management

"Use of acid soaps and body lotions. Trimethylamine is a strong base (pKa 9.8). Thus, at pH 6.0, less than 0.02% of trimethylamine exists as the volatile free base. The use of soaps and body lotions with a pH close to that of normal skin (pH 5.5-6.5) helps retain secretedtrimethylamine in a less volatile salt form that can be removed by washing. "

The most likeliest range of acidic ph washes is probably the 'feminine washes' that have come to the market, many of which contain lactic acid or another gentle acid. Perhaps these can be used for all-over washing too. It might be worth checking your local supermarket, since they are probably a growing market.

This post is intended to promote discussion on the subject of 'acidic washes', rather than posted as fact. The aim being to find out what washes/soaps/gels on the market are 'acidic'.

Neti pot for nasal irrigation

***IMPORTANT: SEE NOTICE ON POST,***

"NETI POT DEATHS LINKED TO BRAIN-EATING AMOEBA IN TAP WATER"

Have you ever tried a nasal rinse treatment for halitosis with a netti/neti pot using baking soda and salt? I find it helps just as the bath does for the body.

It is very inexpensive, and you can get the netti pot at your local pharmacy. You can mix half of 1/4 tsp of salt (without iodine) and 1/4 tsp of baking soda inside your netti pot with warm distilled water (or boiled tap water). My doctor suggests that the salt not contain iodine because it may be irritating.

Here’s a video that shows you how it works. This nasal rinse was recommended to me by my allergy and asthma doctor and by my acupuncturist to treat infection and to remove allergens that may be lodged in my nasal passages. By removing the odorous mucous layer that sits in your sinuses and may cause post-nasal drip, it helps remove the odor. If you have a minor sinus infection, it ia usually resolves it in a matter of a few days, if not sooner, unless the infection is very bad.

Dry skin brushing

Skin brushing stimulates the lymph system, which would be the main reason it is mentioned in the case of bloodborne body odor or halitosis. We have to assume it won't help, or give insignificant help, but it won't hurt (well we hope not :) ). People have different techniques to skin brushing. It is usually done before washing. This video is for example purposes only.



random dry skin brushing link : from www.urbanwellness.com

Income idea : write articles for associatedcontent.com.

Income idea : write articles for associated content .com
http://www.associatedcontent.com/
Income rating : probably very low
Entry level : probably easy but there must be some sort of editorial quality control.

Pages about the income : http://www.associatedcontent.com/faq.html#J

What the main points/rules seem to be (please always check the small print):

• Minimum rate : $1.50 per 1000 page views of all your articles per month
  
• USA only (internationals can write but don't seem to get paid)
• Over 18s only
• Paypal only
  

This writer may have made about $105 on all his articles since March
http://www.associatedcontent.com/article/645667/what_is_trimethylaminuria_or_tmau_and.html?cat=70

This is not an endorsement. Please make sure you research everything about any online company that you chose to work with before undertaking the task, and always read the fine print. Make sure all the terms are clearly defined, such as how you will get paid and how frequently, what work-load is expected of you, etc.

Feel free to suggest any other suitable income ideas

other similar 'paid article' sites :
http://www.ehow.com/write.html

The Barron Report: The Probiotic Miracle

This is one of the best articles on Probiotics out there. I highly recommend it. My thanks to one of our visitors who recommended this reading in the Comment section of this blog. Below are some excerpts of this article under The Best Probiotic Formulas,

A good probiotic formula is absolutely essential for long-term intestinal health, and long-term parasite control. When choosing a probiotic, look for the following characteristics:

• Then there's the question of how many live microorganisms are left in your formula when you actually use it. Pick up any probiotic formula, look at the label, and you'll see something like: "Contains 13 billion live organisms per capsule at time of manufacture." And that's the problem: "at time of manufacture."The die-off rate for probiotics can be astounding. Most formulas will experience a die-off approaching log 3 within just 60 days of manufacture. That means that the 13 billion you see on the label may be down to 13 million, or less, by the time you use it. Heat and moisture accelerate the process, which is why most manufacturers recommend keeping your probiotic supply refrigerated...
• Note: a good probiotic formulation will usually contain fructooligosaccharides (FOS) which help promote the growth of beneficial bacteria. For some friendly bacteria, such as the Bifidus, FOS can increase their effectiveness by a factor of 1,000 times or more!!
  

The article ends with a final note: "...there is a chance that you will precipitate a die-off of bad bacteria in your intestinal tract. This can lead to gas, stomach rumblings and cramping for up to three weeks."

http://www.jonbarron.org/detoxing-health-program/05-01-1999.php

Mitchell/Smith TMAU 2001 paper : Their treatment advice both for then and in the future

The diagnosis of 'TMAU' was first recorded around 1970, and over the last 38 years it is unclear if there is much research attention either in TMAU or the enzyme involved, the Flavin Mono-Oxygenase enzymes (of which FMO3 is by far the most abundant and seemingly most important in humans). FMO are perceived as not having a majorly vital role in humans, and the sense is that few researchers are researching TMAU or the FMO enzymes, hence so few research papers have been published on the subject as well.

This is a well-known paper from 2001, written by 2 of the few researchers in the UK, Dr Steven Mitchell and R. L. Smith. For this post, we quote their long-term ideas as to solutions for TMAU, probably the ultimate goal being gene therapy.

It is unclear if gene therapy is possible today for TMAU. For instance, if it's more to do with no perceived need for it in terms of numbers of sufferers or the perceived seriousness of the problem by the medical establishment, or the cost, or practicalities (such as length of the treatment effect or effectiveness).

As to the future, one may envisage some new approach to treating or managing the condition quite apart from the obvious one of gene therapy with replacement of the human gene for FMO3. Alternative approaches might embrace the following: use of gut absorbents, such as charcoal or ion-exchange resins; modify the gut flora to reduce the bacterial species responsible for the conversion of precursors to trimethylamine; incorporate micro-organisms "engineered" with human FMO3 into the gut flora, to oxidize any trimethylamine released to its non-odorous N-oxide; provide riboflavin supplements, a precursor of the FAD cofactor for flavin monooxygenase function, in an attempt to maximize any residual activity; and finally, from the cosmetic point of view, the development of "malodor suppressants" in hygiene products to disguise the offensive smell of trimethylamine.

http://dmd.aspetjournals.org/cgi/content/full/29/4/517#SEC10

Poll: Bloodborne body odor: Does your gut bloat ?

Bloodborne BO : Does yout gut bloat ?

Secondary TMAU (precursor overload) and testing

It appears to me that the concept of Secondary TMAU caused by precursor overload and/or bacteria overgrowth seems to be only ever mentioned by people tested in the UK, although I am open to seeing documentation to the contrary opinion. I have looked for articles written by US experts supporting this concept described by UK experts, but have not found any so far.

There are so few researchers in trimethylaminuria, and it seems unclear if there is international agreement as to how the guidelines for the testing results parameters for the urine is determined. This is something we need to clarify as a 'community'. Based on the literature I've come across, it appears that in the UK, the few TMAU experts seem to accept that overgrowth of the bacteria that produce trimethylamine can itself be the problem (saturating the normal fmo3 enzyme), even if the fmo3 enzyme is fully functional. They call this 'secondary TMAU' or 'precursor overload'. There doesn't seem to be reported cases of this in the USA or elsewhere. It's something we as a community need clarification on. Of course people can have both primary and secondary (enzyme function too low, and too much bacteria), but it is interesting that a group of experts are willing to accept 'overload' alone can be a cause, whereas so few (if any) elsewhere seem to mention secondary TMAU.

It appears to me that this means at least some experts accept the principle of 'overgrowth' being a potential cause.

In this case (if the assumption is correct), the patient only seems to be positive for secondary TMAU in the urine test, and consequently they conclude he is positive for primary TMAU from the DNA test.
http://www.ncbi.nlm.nih.gov/pubmed/12653714

The following is a quote from a paper written by experts who accept (perhaps introduced) the concept of Secondary TMAU :

"Substrate overload of FMO3 enzyme activity resulting from either an excess of dietary precursors of TMA or variations in gut fauna, causing increased release of TMA. This type of trimethylaminuria is characterized by a high concentration of TMA in the urine, but a normal urinary TMA/TMA N-oxide ratio."

http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&partid=1103

So it raises the question; has anyone in the USA or anywhere apart from the UK been tested for 'secondary TMAU' ?

Prebiotics

While probiotics are the actual friendly bacteria (hopefully, depending on what the manufacturer put in the capsules), prebiotics are regarded as the food for the desirable bacteria. They usually discriminately favor desirable bacteria (to different degrees of specifity), such as bifidogenic meaning they are good food specifically for bifidobacteria. As well as being naturally in certain foods, prebiotics can also be bought as a separate supplement and often are added to probiotics. Common prebiotics used are fructooligosaccharide powder and/or inulin. If bloodborne body odor or bloodborne halitosis had a dysbiosis connection (often sufferers feel they have a gut ecology problem), then perhaps prebiotics could play a role along with probiotics. The NIH recommend lactulose for trimethylaminuria.

Prebiotic (nutrition)

According to Gibson and Roberfroid as referred to in Wikipedia, prebiotics are functional and beneficial non-digestible food ingredients that “selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon, and thus improve host health.” The most prevalent forms of prebiotics are nutritionally classed as soluble fiber. To some extent, many forms of dietary fiber exhibit some level of prebiotic effect.

Sources of prebiotics:

Traditional dietary sources of prebiotics include soybeans, inulin sources (such as Jerusalem artichoke, jicama, and chicory root), raw oats, unrefined wheat, unrefined barley and yacon. Some of the oligosaccharides that naturally occur in breast milk are believed to play an important role in the development of a healthy immune system in infants, but these are not considered prebiotics, as they do not act through the intestinal microflora.

Prebiotic oligosaccharides are increasingly added to foods for their health benefits. Some oligosaccharides that are used in this manner are fructooligosaccharides (FOS), xylooligosaccharides (XOS), polydextrose and galactooligosaccharides (GOS). Some monosaccharides such as tagatose are also used sometimes as prebiotics.

http://en.wikipedia.org/wiki/Prebiotic_(nutrition)
http://www.food-info.net/uk/ff/prebiotics.htm

Monday morning Pep talk

Colonic irrigation : A demonstration video

It has to be currently assumed that colonic irrigation will have no direct benefit on bloodborne body odor or halitosis. However, often sufferers may think it makes sense to do so. This video is posted so that anyone interested has an idea of what to expect. The post is not intended as a recommendation or a criticism of colonic irrigation. Colonic Therapists will have different approaches to the hydrotherapy. For example some give a probiotic implant at the end, while others don't. Please do your own research.



a C.I. therapist explains : http://www.youtube.com/watch?v=RzZYllc-QwE

more youtube searches : http://www.youtube.com/results?search_query=colon+hydrotherapy

What are probiotics?

In his book, the editor, Roy Fuller stresses the need for a probiotic to be viable when he redefines probiotics in 1989 as "A live microbial feed supplement which beneficially affects the host animal by improving its intestinal microbial balance." Not all probiotic products in the market are viable by the time they reach the shelves, and thus do not have the same potency and desired effects.

Fuller goes on to list the wide range of lactobacilli generally used in probiotics , "Currently available probiotic preparations contain L. delbreuckii subsp. bugaricus, L. acidophilus, L. casei, L. fermentum. L. plantarum, L. brevis, L. cellobiosus, L. lactis and L. reuteri."

In 1905, Tissier showed that bifidobacteria were the dominant bacteria in the gut of brest-fed infants, and from his work stems the use of bifidobacteria used as probiotics, which are, "Bifidobacterium adolescentis, Bif. animalis, Bif. bifidum, Bif. infantis, Bif. longum, and Bif. thermophilum."

In sour milk and yogurts we find the first use of streptococci as probiotics, with the yogurt starter S. salivarius subsp. thermophilus currently being a common probiotic organism.

Book: Fuller, R. (Ed.). (1992). Probiotics, The scientific basis. London: Chapman & Hall.

Probiotics: Metabolic interactions in the gut

This is a precise summary of the benefits of probiotics by Ian R. Rowland from a 1992 book by probiotics expert, Roy Fuller.

One of the most important ways in which a probiotic organism may exert a beneficial effect on its host is to modify metabolic processes, particularly those occurring in the gut. Such a beneficial effect could be achieved in theory by a variety of mechanisms:

1. By suppressing reactions which result in the generation of toxic or carcinogenic metabolites.
2. By stimulating enzymic reactions involved in detoxification of potentially toxic substances, either ingested or formed endogenously.
3. By stimulating mammalian enzymes involved in the digestion of complex nutrients, or when such enzymes are absent (due to genetics or disease) providing a bacterial source of these enzymes.
4. By synthesizing vitamins and other essential nutrients not provided in sufficient quantities in the diet...
   

Book: Fuller, R. (Ed.). (1992). Probiotics, The scientific basis. London: Chapman & Hall.

Another article from Fuller, R (1991) : from pubmed central

Positivity : Tai Chi ; Simplified Yang 24 style

the zinc taste test

Testing is probably the best policy if you have a bloodborne odor problem. Any home test is likely to be more popular. If you have a bloodborne odor problem, it may be worthwhile ruling any deficiences out. In the case of vitamins and minerals testing, this is a home test that is supposed to give a general rough assessment of your zinc status. The senses of taste and smell are supposed to be associated with gustin, a polypeptide dependent on zinc that is suspected to be a taste bud growth factor. The 'taste test' was devised by Professor Derek Bryce-Smith of Reading University. The zinc solution can be bought online. In the USA there is a brand called Zinc Tally, but there are probably cheaper brands.

External Body Odor has been (tenuously ?) associated with zinc, and zinc is also associated with smell/taste function, but it should be deemed very unlikely zinc deficiency play a role in a bloodborne odor problem. Also, the dosages suggested in the link are not a recommendation here. Zinc toxicity can make you feel unwell.

This site explains the Zinc taste test protocol...
http://www.uspharmacist.com/index.asp?show=article&page=8_1546.htm

1)Optimal zinc levels—An immediate, unpleasant, obviously adverse taste.
2)Adequate Zinc Levels—A definite but not strongly unpleasant taste is noted immediately and tends to intensify with time.
3)Quite Zinc Deficient—No taste noted initially, but develops in 10-15 seconds.
4)Very Zinc Deficient—Tasteless or “tastes like water”

related links:
pubmed search : zinc taste test
video: http://tuesdayminute.net/zinc.html(not an endorsement)
http://www.horstpharmacy.com/Zinc.asp
zinc and taste perception : http://www.greenmarket.com/Library/Bookshelf/Books/10/110.cfm
gustin study: http://www.tasteandsmell.com/jun04.htm

Poll : see below

leaky gut - Liz Lipski booklet

Liz Lipski is a well-known and respected practitioner of natural medicine in the USA. She has written a few books on gut health problems. She wrote a brief booklet a while back on 'leaky gut' (gut permeability). Here are some excerpts from the booklet. Info on leaky gut (gut permeability) is posted, since people with bloodborne body odor or halitosis often seem to have gut issues. The best way to find out if you had leaky gut, would be to test.

http://books.google.com/books?id=rGs7cj5UYZUC&printsec=frontcover

related links :

an example of a 'leaky gut' supplement brand (Not an endorsement. There are many brands, probably cheaper) : from Metagenics

interesting papers on 'leaky gut' :
leaky gut and depression: http://www.ncbi.nlm.nih.gov/pubmed/18283240
leaky gut and alcoholic liver disease: http://www.ncbi.nlm.nih.gov/pubmed/18162065
pubmed search : "leaky gut" OR "gut permeability"

2005 paper : variations in fmo3 function with polymorphic genes

With bloodborne odors, presumably one or more of the enzymes in the body are past saturation point for some reason (whether excess load or a genetic weakness or a combination, or other reason). One of the most likely enzyme candidates for bloodborne odors is the FMO family of enzymes (in humans, mostly FMO3).

The flavin-containing monooxygenases (FMOs) are a family of NADPH and oxygen-dependent microsomal enzymes involved in the oxidative metabolism of many nucleophilic nitrogen-, sulfur- and phosphorous-containing drugs and toxicants. They are important for xenobiotic metabolism. FMO3, the predominant FMO enzyme in human adult liver, exhibits significant interindividual variation that is poorly understood.

This 2005 paper was written by a group of Researchers at the Departments of Pediatrics and Pharmacology/Toxicology, Medical College of Wisconsin, Milwaukee. They tested the DNA from 201 Hispanic-American (Mexican descent), 201 African-American, and 200 non-Latino White (northern European descent) subjects to identify common FMO3 genetic variants and determine their potential for contributing to interindividual differences in FMO3 expression. Seven common (>1%) promoter region haplotypes were inferred in one or more of the study populations that differed in estimated frequency among the groups. Haplotype 2 resulted in an 8- fold increase in promoter activity, while haplotype 8 and 15 exhibited a near complete loss of activity.

Discovery of Novel Flavin-Containing Monooxygenase 3 (FMO3) Single Nucleotide Polymorphisms and Functional Analysis of Upstream Haplotype Variants

Sevasti B. Koukouritaki, Mark T. Poch, Erwin T. Cabacungan, D. Gail McCarver, and Ronald N. Hines
Departments of Pediatrics and Pharmacology/Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA 53226

Full paper : From Pubmed Central site

These are some points of note from the paper :

" human FMO3 is essentially nondetectable in fetal liver, but is observed in most individuals by 1 to 2 years of age...

...Ten- to twenty-fold differences in interindividual FMO expression have been reported that may contribute to an individual’s susceptibility to toxicants and/or response to drugs (Overby et al., 1997; Yeung et al., 2000; Koukouritaki et al., 2002)...

...Thirty genetic variants in human FMO3 coding sequences have been characterized. Thirteen of these are single nucleotide changes that result in loss of function and represent rare alleles causative for trimethylaminuria (TMAU) or "fish-odor syndrome" (for review, see Cashman, 2004). In addition, a homozygous deletion of exons 1 and 2 was reported as causative in an Australian of Greek ancestry with TMAU (Forrest et al., 2001). However, the substantial differences in FMO3 expression observed within or among different populations (Overby et al., 1997; Yeung et al., 2000; Koukouritaki et al., 2002) cannot be attributed to such rare alleles. Rather, common variants encoding an altered, but functional FMO3 must contribute. Three of the 30 known human FMO3 genetic variants (E158K, V257M, and E308G) are common (i.e., allelic frequencies >1%), two of which are associated with reduced FMO3 activity (for review Cashman, 2004). However, considering the percent loss of activity and their frequency, these variants would not fully explain observed interindividual differences in FMO3 expression...

...Hispanic-Americans of Mexican descent, African-Americans, and non-Latino Whites of northern European descent. Haplotype 2 (g.-2650C>G, g.-2543T>A, and g.-2177G>C), exhibited an 8-fold increase in FMO3 promoter activity [probably a good thing], and, combined with its estimated frequency, would be expected to have a significant impact on FMO3 expression and FMO3-dependent xenobiotic metabolism within all three populations. Although haplotype 2's frequency differed among these groups (Table 7), assuming conformity to the Hardy-Weinberg equilibrium, it is anticipated 49.4%, 20.6% and 12.2% of Hispanic-Americans of Mexican descent, African-Americans, and non-Latino Whites of northern European descent, respectively, would possess at least one of the haplotype 2 alleles...

...In contrast to the increased promoter activity observed with haplotype 2, a nearly complete loss of promoter function was observed with haplotypes 8 and 15. Interestingly, haplotypes 8 and 15 were only estimated as common in the Non-Latino White-American and African-American study populations, respectively. Again assuming conformity to the Hardy-Weinberg equilibrium, at least one haplotype 15 allele would be observed in 3.0% of African-Americans while the haplotype 8 allele would be observed in 7.3% of Non-Latino White-Americans...

...The frequencies of these functionally significant alleles in the three population groups strongly suggests that genetic diversity within the FMO3 promoter contributes substantially to observed interindividual differences in FMO3 expression levels. Further, the apparent absence of the loss of function haplotypes 8 and 15 in the Hispanic-American study population combined with the relative abundance in this group of the gain of function haplotype 2 allele would be consistent with FMO3 mean expression being higher in Hispanic-Americans. ..

...Both haplotype 8 and haplotype 15 share a common SNP, i.e., g.-2106G>A, suggesting that this transition may be responsible for the dramatic loss of promoter activity...

...The magnitude of loss of function for haplotypes 8 and 15, suggests both these alleles might contribute to the incidence of trimethylaminuria in the Non-Latino White-American and African-American populations, respectively...

...Studies on individuals heterozygous for structural FMO3 null variants suggest that a 50% loss of metabolic capacity to N-oxidize trimethylamine does not result in an overt trimethylaminuria phenotype, but only renders such individuals susceptible to a trimethylamine challenge (Zschocke et al., 1999). Thus, assuming conformity to the Hardy-Weinberg Equilibrium, one would predict that only individuals homozygous for either haplotype 8 at a frequency of 0.1% in the Non-Latino White-American population or haplotype 15 at a frequency less than 0.1% in the African-American population would present with symptoms for this disorder. In contrast, a 50% loss of metabolic activity in the more frequent heterozygotes may significantly impact FMO3-dependent drug metabolism...

...In summary, a total of 40 FMO3 SNPs have been identified, 27 of which are novel...

... These observations suggest that genetic variation within FMO3 regulatory sequences will contribute to differences in FMO3 metabolic capacity both within and among different populations. Further, these differences may well contribute to differential susceptibility to environmental toxicants and adverse drug reactions both on an individual and population basis. "

Genes for dummies: a simple video guide (4 parts)

This video gives a simple explanation of the basics of genetics. TMAU is a rare genetic disease that produces body odor, and there may well be other genetic metabolic disorder that may also produce odorous bloodborne toxins, so further exploration of these genes will be discussed in this blog.


Click below to see parts 2,3 and 4

Co-factors/co-enzymes in enzyme reactions

*unqualified post intended to promote clarification/research :

Many human enzymes require a cofactor for their reaction to take place. In the case of fmo3, B2 (Riboflavin) is needed ?

In theory, if you are deficient in the cofactor, you could in theory end up suffering a version of the problem associated with that enzyme ? For instance possibly B2 deficiency could result in a positive primary trimethylaminuria in a urine test? FMO3 seems to depend on Flavin adenine dinucleotide (FAD), which is derived from B2 (?). However, whatever medical advice was given regards trimethylaminuria results should be regarded as them taking responsibilty for your diagnosis. At the moment it must be deemed unlikely (until research is done) a vitamin/mineral deficiency would be a factor in bloodborne body odor or halitosis issues.

(Unverified) list of vitamins/minerals that are cofactors in human enzymes
http://www.expasy.ch/enzyme/enzyme-bycofactor.html

Reference links :
http://www.chemistryexplained.com/Ce-Co/Coenzyme.html
http://www.encyclopedia.com/doc/1E1-coenzyme.html
http://en.wikipedia.org/wiki/Coenzyme
http://en.wikipedia.org/wiki/Cofactor_(biochemistry)

Video : introduction to probiotics

This seems to be an advert for a specific probiotic brand, but is posted rather for the educational purpose, since it's a good intro to probiotics. Please do not take it as a recommendation of the brand. There are many brands out there.

Poll: Bloodborne body odor: Does alcohol ever make your kidneys hurt

Poll: Bloodborne body odor: Does alcohol ever make your kidneys hurt ?

1997 paper : Trimethylaminuria associated with seizures and behavioural disturbance: a case report

This anecdotal case study medical paper from 1997 includes 2 names who are well-known in FMO3 research in the UK (Mitchell, Smith). FMO3 is involved in the detoxication/activation of many substances (both internal and absorbed), and in this case they seem to be suggesting the seizures and psychiatric disturbance were secondarily related to his TMAU symptom. Only the abstract is available for free.

McConnell HW, Mitchell SC, Smith RL, Brewster M.

Centre for Epilepsy, Maudsley Hospital, London, UK.

A 16-year-old left-handed male is presented with a history of seizures associated with a fish-like odour and behavioural disturbances thought to be related to trimethylaminuria. His seizures were complex-partial (cursive) seizures and started at the age of 18 months. They occurred in the context of discrete episodes several times per year. The episodes would start with a fish-like odour, followed by seizures occurring in clusters and behavioural disturbance consisting of agitation, mixed affective symptoms, auditory hallucinations and delusions. A urinary assay of trimethylamine (TMA) was elevated, confirming the diagnosis of trimethylaminuria in this patient...

http://www.ncbi.nlm.nih.gov/pubmed/9304724

Positivity : Sport psychology lesson

2002 Bibliography prepared for the 2nd TMAU workshop : 1% may be affected ?

This 163 citations bibliography (January 1999 through August 2001) was prepared in support of the Second Workshop on Trimethylaminuria* held at the National Institutes of Health (NIH) on March 15-16, 2002, in Bethesda, Maryland

Full article : http://www.nlm.nih.gov/archive//20061214/pubs/cbm/trimethylaminuria_update.html

PDF format : http://permanent.access.gpo.gov/lps536/www.nlm.nih.gov/pubs/cbm/trimethylaminuria_update.pdf

Of particular interest is the introduction, where they elaborate on the general assumptions on TMAU from a genetic viewpoint at the time.

These include :

Many researchers believe that there are several types of TMAU caused by a "spectrum" of changes in the gene which controls the formation of the flavin-containing monooxygenase 3 (FMO3) enzyme. In humans, this is an important liver enzyme that controls the metabolism of substances such as TMA. The most severe form of TMAU appears to be caused by mutations in the FMO3 gene; these mutations appear inherited in an autosomal recessive fashion. Studies are leading many researchers to conclude that the less severe forms of TMAU are caused by several non-benign genetic polymorphisms in the FMO3 gene. Genetic polymorphisms are changes in the gene structure that may be fairly common in the population; however, for reasons, which are not well understood, these changes lead to TMAU-symptoms in certain individuals.

It is estimated that as much as one percent of the U.S. population may suffer from TMAU, but its true incidence is not yet known. But whether it is one or one-tenth of one percent, we know that the condition affects people of both sexes and of all ages and races from around the world. Currently there are more than 300 people with a malodor disorder on the Trimethylaminuria Support Group's mailing list, with many more preferring to remain anonymous because of the often-associated stigma, negative and harassing behaviors targeted at some, and the general lack of medical and other support.

Dr Hyman video series of 7 : UltraWellness Key #1: Convince Your Genes to Turn on Health

The Sunday fortnightly MSN support group Body odor & Halitosis free phone conferences

Free USA-based phone conferences
General Conferences: normally every other Sundays 2pm EST.

For USA-based : (712) 432 1620 then type the access code on your phone keypad: 391629#
Non USA : prefix above with 001 but check to see if it is free with your supplier

Record number of callers : 70+
If privacy is a concern, code your phone to PRIVATE mode
This phoneline can be used anytime to talk to other sufferers

see the forum for details
http://groups.msn.com/BodyOdorSupport/general.msnw

Extract about "unusual odors" in the book : Inherited Metabolic Diseases

By Georg F. Hoffmann, William L Nyhan, Johannes Zschocke, Stephen G Kahler, Ertan Mayatepek

Chapter 4. When to Suspect Metabolic Diseases Unusual Odor (pgs. 23 – 25)

This section alerts the physician to a number of metabolic diseases with symptoms of unaccustomed odors, such as animal-like maple syrup, acrid short-chain acid, cabbage, rancid butter, and rotten fish. Table 4.1, Diagnostic utility of unusual odors describes the type of odor, the substance of that odor, and the disorder it represents.

extract about unusual odors from the book : Inherited Metabolic Diseases

Positivity : Neuro-linguistic programming

http://en.wikipedia.org/wiki/Neuro-linguistic_programming
http://www.nlpinfo.com/

Gut candidiasis (candida overgrowth) : The most common form of dysbiosis

It is unknown if dysbiosis is a factor in bloodborne BO/Halitosis. Dysbiosis can be caused by mostly bacteria and/or parasites and/or fungus overgrowth or inappropriate growth in the gut. Candida albicans (a fungus) is said to be the most common dysbiosis problem (either on it's own or as one of the pathogens present). Dr Orian Truss is regarded as the pioneer in discovering the link between health issues and gut candidiasis in the late 70s, and the late Dr William Crook is best known for popularising this hypothesis since the early 80s. Here is a website he started, now continued in his name and for his cause. Candida should alway be a chief suspect if you feel you have a low-grade gut infection, but it shouldn't be exclusively ruled in, or other factors be ruled out. Testing is probably the best policy. Dr Crook does an anecdotal questionaire, but nothing can be concluded from that.

http://www.yeastconnection.com/
Dr Podell explains the history of the gut candida overgrowth hypothesis

Medical paper 2007 : Transient trimethylaminuria related to menstruation

Transient trimethylaminuria related to menstruation
Shimizu M, Cashman JR, Yamazaki H

The results of this study conducted by the respected FMO3 geneticist expert Dr. Cashman of HRBI, and Drs. Shimizu and Yamazaki in 2007 suggest that sex hormones play a role in reducing FMO3 function on days around menstruation. "Menses can be a factor causing transient trimethylaminuria even in healthy women harboring active enzymes. The present information could be useful in relieving the symptoms for transient and/or mild trimethylaminuria for affected females during menstruation."

full article: http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17257434

Points of note :

"Herein, we describe data to support the proposal that menses can be an additional factor causing transient trimethylaminuria in self-reported subjects suffering from malodor and even in healthy women harboring functionally active flavin-containing monooxygenase 3 (FMO3).

...For Case (B) that was homozygous for common [Glu158Lys; Glu308Gly] FMO3 polymorphisms, metabolic capacity of FMO3 was almost ~90%, except for a few days surrounding menstruation showing <> 90%) metabolic capacity, however, on days around menstruation the FMO3 metabolic capacity was decreased to ~60–70%.

...Conclusion
Together, these results indicate that abnormal FMO3 capacity is caused by menstruation particularly in the presence, in homozygous form, of mild genetic variants such as [Glu158Lys; Glu308Gly] that cause a reduced FMO3 function.

...The causal factor of excessive free trimethylamine is reduced enzyme capacity, or maybe substrate overload. The decreased enzyme capacity to form non-odorous trimethylamine N-oxide could be a result by an inherited deficiency (primary genetic trimethylaminuria) and/or by hormonal modulation or liver damage (transient trimethylaminuria) [2,3]. For trimethylaminuria, at least 40 genetic polymorphisms of the flavin-containing monooxygenase 3 (FMO3) gene have been reported [4,5]. For transient trimethylaminuria, a change of metabolic capacity in one individual around the time of menstruation has been reported [6]. Herein, we describe data to support the proposal that menses can be an additional factor causing transient trimethylaminuria in self-reported subjects suffering from malodor and even in healthy women harboring functionally active FMO3.

...Together, these results indicate that abnormal FMO3 capacity is caused by menstruation particularly in the presence, in homozygous form, of mild genetic variants such as [Glu158Lys; Glu308Gly] that cause a reduced FMO3 function. This would further suggest that sex hormones play a role in the variable regulation of FMO3. Induced FMO3 activity during pregnancy [8has been reported."